Journal ArticleDOI
Contractions, a risk for premature rupture of fetal membranes: a new protocol with cyclic biaxial tension.
Michela Perrini,Wilfried Bürzle,Claudia Haller,Nicole Ochsenbein-Kölble,Nicole Ochsenbein-Kölble,Jan Deprest,Roland Zimmermann,Roland Zimmermann,Edoardo Mazza,Edoardo Mazza,Martin Ehrbar,Martin Ehrbar +11 more
TLDR
Cyclic testing demonstrated a large hysteresis loop and irreversible deformation on the first cycle, followed by rapid stabilization on subsequent cycles, thus indicating that contractions might increase the risk of premature rupture of the membrane.About:
This article is published in Medical Engineering & Physics.The article was published on 2013-06-01. It has received 23 citations till now.read more
Citations
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Journal ArticleDOI
Second harmonic generation microscopy of fetal membranes under deformation: normal and altered morphology.
Arabella Mauri,Michela Perrini,Michela Perrini,José María Mateos,Caroline Maake,N. Ochsenbein-Koelble,Roland Zimmermann,Martin Ehrbar,Edoardo Mazza,Edoardo Mazza +9 more
TL;DR: Second harmonic generation microscopy has been used to visualize the microstructure of fetal membranes for the first time and repeated mechanical loading was shown to affect the integrity of the amnion-chorion interface which might indicate an increased risk of premature rupture of fetal membrane.
Journal ArticleDOI
Deformation mechanisms of human amnion: Quantitative studies based on second harmonic generation microscopy.
Arabella Mauri,Alexander E. Ehret,Michela Perrini,Michela Perrini,Caroline Maake,Nicole Ochsenbein-Kölble,Martin Ehrbar,Michelle L. Oyen,Edoardo Mazza,Edoardo Mazza +9 more
TL;DR: Dedicated microscopic tools for in situ mechanical characterization of tissue under applied mechanical loads and the related methods for data interpretation are presented with emphasis on new stepwise monotonic uniaxial experiments, resulting microscopic parameters are consistent with previous ones quantified for cyclic and relaxation tests, underlining the reliability of these techniques.
Journal ArticleDOI
Time-dependent mechanical behavior of human amnion: macroscopic and microscopic characterization.
Arabella Mauri,Michela Perrini,Michela Perrini,Alexander E. Ehret,Davide S.A. De Focatiis,Edoardo Mazza,Edoardo Mazza +6 more
TL;DR: The present data indicate that dissipative behavior of human amnion is related to two mechanisms: volume reduction due to water outflow and long-term dissipative behaviors without macroscopic deformation and no systematic global reorientation of collagen fibers.
Journal ArticleDOI
Mechanical and Microstructural Investigation of the Cyclic Behavior of Human Amnion
Michela Perrini,Michela Perrini,Arabella Mauri,Alexander E. Ehret,Nicole Ochsenbein-Kölble,Roland Zimmermann,Martin Ehrbar,Edoardo Mazza,Edoardo Mazza +8 more
TL;DR: The structural and mechanical integrity of amnion is essential to prevent preterm premature rupture of the fetal membrane and differences between the investigated configurations in the deformation and microstructural mechanisms revealed.
Journal ArticleDOI
Tocolysis for in utero Surgery: Atosiban Performs Distinctly Better than Magnesium Sulfate.
Nicole Ochsenbein-Kölble,Franziska Krähenmann,M Hüsler,Martin Meuli,Ueli Moehrlen,Lucca Mazzone,Peter Biro,Roland Zimmermann +7 more
TL;DR: The authors suggest using atosiban instead of magnesium sulfate in the context of open fetal surgery, as it resulted in an almost identical short-term uterine outcome without any serious maternal complications as seen when magnesium sulfATE was given.
References
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Journal ArticleDOI
Large Deformation Isotropic Elasticity—On the Correlation of Theory and Experiment for Incompressible Rubberlike Solids
TL;DR: In this article, the correlation of theory and experiment for incompressible isotropic elastic solids under finite strain was extended to incorporate the effects of compressibility (under isothermal conditions) with the result that experimental data on the compressibility of rubberlike materials are adequately accounted for.
Journal ArticleDOI
Large Elastic Deformations of Isotropic Materials. VII. Experiments on the Deformation of Rubber
R. S. Rivlin,D. W. Saunders +1 more
TL;DR: In this paper, it was shown that the load-deformation curves obtained for certain simple types of deformation of vulcanized rubber test-pieces in terms of a single stored energy function can be interpreted on the basis of the theory of large elastic deformations of incompressible isotropic materials.
Book ChapterDOI
Large Elastic Deformations of Isotropic Materials
TL;DR: In this paper, the equilibrium of a cube of incompressible, neo-Hookean material, under the action of three pairs of equal and oppositely directed forces f 1, f 2, f 3, applied normally to, and uniformly distributed over, pairs of parallel faces of the cube, is studied.
Journal ArticleDOI
Large Deformation Isotropic Elasticity—On the Correlation of Theory and Experiment for Incompressible Rubberlike Solids
TL;DR: In this article, the results of that work are extended to incorporate the effects of compressibility (under isothermal conditions) and the strain energy function constructed for incompressible materials is augmented by a function of the density ratio with the result that experimental data on the compressibility of rubberlike materials are adequately accounted for.
Journal ArticleDOI
The Physiology of Fetal Membrane Rupture: Insight Gained from the Determination of Physical Properties
TL;DR: The model has been used to establish the physical properties of individual fetal membrane components, determine the sequence of events during the fetal membrane rupture process, and demonstrate that treatment of fetal membranes with TNF or IL-1beta, in vitro, induces weakness and the identical biochemical markers of collagen remodeling and apoptosis seen in the physiological weak zone.