Correction of congenital diaphragmatic hernia in utero. I. The model: intrathoracic balloon produces fatal pulmonary hypoplasia.
TLDR
This model of a progressively enlarging intrathoracic mass which produces severe pulmonary hypoplasia and fatal respiratory insufficiency simulates the pathophysiology of congenital diaphragmatic hernia in human neonates.About:
This article is published in Surgery.The article was published on 1980-07-01 and is currently open access. It has received 254 citations till now. The article focuses on the topics: Congenital diaphragmatic hernia & Pulmonary hypoplasia.read more
Citations
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Journal ArticleDOI
A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia.
Michael R. Harrison,Roberta L. Keller,Samuel Hawgood,Joseph A. Kitterman,Per L. Sandberg,Diana L. Farmer,Hanmin Lee,Roy A. Filly,Jody A. Farrell,Craig T. Albanese +9 more
TL;DR: Tracheal occlusion did not improve survival or morbidity rates in this cohort of fetuses with congenital diaphragmatic hernia and was inversely related to survival in both groups.
Journal ArticleDOI
Correction of congenital diaphragmatic hernia in utero: VI. hard-earned lessons
Michael R. Harrison,N. Scott Adzick,Alan W. Flake,Russell W. Jennings,James M. Estes,Thomas E. MacGillivray,Jane T. Chueh,James D. Goldberg,Roy A. Filly,Ruth B. Goldstein,Mark A. Rosen,Charles Cauldwell,Anne H Levine,Lori J. Howell +13 more
TL;DR: It is reported that repair of CDH in utero is physiologically sound and safe for the mother, but technically difficult especially when the liver is herniated into the fetal chest.
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Diaphragmatic hernia in the fetus: Prenatal diagnosis and outcome in 94 cases***
N. Scott Adzick,Michael R. Harrison,Philip L. Glick,Donald K. Nakayama,Frank A. Manning,Alfred A. deLorimier +5 more
TL;DR: Surgical intervention before birth may be necessary to improve survival of the fetus with CDH and polyhydramnios and current techniques can detect lethal nonpulmonary anomalies and prevent diagnostic errors.
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Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia
John W. DiFiore,Dario O. Fauza,Richard Slavin,Craig A. Peters,James C. Fackler,Jay M. Wilson +5 more
TL;DR: Experimental fetal DH produces hypoplastic lungs that are not capable of adequate gas exchange with conventional ventilation and are associated with a normal maturation pattern based on histological appearance, normal airspace fraction, and normal alveolar numerical density.
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Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation.
Michael T. Longaker,David J. Whitby,N. Scott Adzick,Timothy M. Crombleholme,Jacob C. Langer,Brian W. Duncan,Scott M. Bradley,Robert S. Stern,Mark W. J. Ferguson,Michael R. Harrison +9 more
TL;DR: A highly sensitive immunohistochemical technique that uses antibodies to collagen types I, III, IV, and VI found that collagen was deposited in fetal wounds much more rapidly than in adult wounds.
References
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Lung hypoplasia in congenital diaphragmatic hernia. A quantitative study of airway, artery, and alveolar development.
TL;DR: From a case of congenital diaphragmatic hernia the pattern of growth of the airways, alveoli, and pulmonary arteries of both lungs, each hypoplastic, has been analysed quantitatively.
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Congenital diaphragmatic hernia: The hidden mortality
TL;DR: From 1969 to 1975, 33 cases of congenital diaphragmatic hernia were treated at the National Hospital of Norway with a "visible" or operative mortality of 30%.
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Congenital diaphragmatic hernia as a cause of perinatal mortality.
Neville Butler,A.E. Claireaux +1 more
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Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic hernia.
TL;DR: It is concluded that the decreased total size of the pulmonary vascular bed and the decreased number of pulmonary vessels per unit lung tissue, causing a fixed high pulmonary vascular resistance, is responsible for the failure of intravenous therapy with tolazoline HCl to improve systemic oxygenation.
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Morphological development of the pulmonary vascular bed in fetal lambs.
TL;DR: The results indicate that increased pulmonary blood flow and decreased pulmonary vascular resistance with advancing gestation are due to an increase in the total number of vessels and increased vasomotor reactivity is related to an increased in thetotal amount of smooth muscle while the thickness of muscle in individual vessels remains constant.