Journal ArticleDOI
Depigmentation caused by phenolic detergent germicides.
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From data, it appears that virtually any moderately irritating phenolic compound can depigment skin, but of those tested, paratertiary butyl and amylphenol most often depigmented skin without producing toxic inflammation.Abstract:
To my knowledge, this is the first report of depigmentation of the skin caused by phenolic germicidal disinfectants. Patch tests with phenolic components of the disinfectants produced depigmentation on 12 affected workers and six volunteer controls. From my data it appears that virtually any moderately irritating phenolic compound can depigment skin, but of those tested, paratertiary butyl and amylphenol most often depigmented skin without producing toxic inflammation. These two phenols are components of many germicidal disinfectants.read more
Citations
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Journal Article
Guideline for disinfection and sterilization in healthcare facilities, 2008
William A. Rutala,David J. Weber +1 more
TL;DR: There is no evidence that using antiseptics or disinfectants selects for antibiotic-resistant organisms in nature or that such mutants survive in nature.
Disinfection, Sterilization Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008
William A. Rutala,David J. Weber +1 more
Journal ArticleDOI
A new formula for depigmenting human skin.
Albert M. Kligman,Isaac Willis +1 more
TL;DR: The formula was therapeutically effective in treatment of melasma, ephelides, and postinflammatory hyperpigmentation and Senile lentigines were resistant to this therapy.
References
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Journal ArticleDOI
Quantitative and Qualitative Data on the Pigment Cells of Adult Human Epidermis1
TL;DR: The morphology and physiology of the melanocyte have been studied thoroughly by numerous investigators, but conflicting statements concerning several basic points, and insufficient data concerning others were found in recent literature.
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Depigmentation of skin with 4-isopropylcatechol, mercaptoamines, and other compounds.
TL;DR: 4-Isopropylcatechol (4-IPC), hitherto unrecognized as a depigmenting agent, appears to be the most potent of all the compounds so far tested and appears to result from a selective action on melanocytes; they are either destroyed or inactivated.
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Occupational Leukoderma. Preliminary Report.
TL;DR: Patch tests performed on the affected workers with the chemicals in the gloves showed that an antioxidant caused positive reactions on all of them, and after a few days when the inflammation eased, the workers resumed work.
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The SLS provocative patch test in allergic contact sensitization.
TL;DR: The promoting effect of provocative tests is mediated by assuring penetration into the immunologic target tissue by damaging the horny layer barrier and by initiating a mild inflammatory response which conditions the tissue to react in an exaggerated but specific way to allergens.