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Effect of Arecoline on Spontaneous Peristalsis of Isolated Ileum

Pla Guangzhou
TLDR
It has been proved that Arecoline significantly enhances spontaneous contraction of isolated ileum in guinea pigs, and has doseeffect dependence relationship.
Abstract
Arecoline is a muscarineCholinergic receptorstimulantIt has been proved that Arecoline significantly enhances spontaneous contraction of isolated ileum in guinea pigs, and has doseeffect dependence relationshipThe effect of Arecoline on enchancing the contraction amplitude of isolated ileum is significant, but the effect of enchancing the contraction frequency is little95.2 mg/kg PO of Arecoline continuously for 7 days had no adverse effect in miceThis dosage is 13.8 times as much as the clinical dosage in human beings

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