Open AccessJournal Article
Effect of high arsenic content in drinking water on rat brain.
TLDR
There was increased lipid peroxidation at all doses of arsenic, including the 'permissible limit', decrease in glutathione level, superoxide dismutase and glutATHione reductase activities, indicating the free-radical-mediated degeneration of brain.Abstract:
The permissible limit of arsenic content in drinking water is 0.05 ppm, whereas, in many parts of West Bengal the arsenic level in drinking water is 0.1 ppm, frequently 0.3 ppm and even 3.0 ppm, though rarely. In order to assess possible risk to brain function by drinking such water, rats were given arsenic mixed in drinking water at the above four concentrations for 40 days. There was increased lipid peroxidation at all doses of arsenic, including the 'permissible limit', decrease in glutathione level, superoxide dismutase and glutathione reductase activities, indicating the free-radical-mediated degeneration of brain.read more
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Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site.
Robert O. Wright,Chitra Amarasiriwardena,Alan D. Woolf,Alan D. Woolf,Rebecca Jim,David C. Bellinger,David C. Bellinger +6 more
TL;DR: Children's general intelligence scores, particularly verbal IQ scores, were significantly related, inversely, to hair Mn and As levels, as were scores on tests of memory for stories and a word list, which suggest the need to study further the neuropsychological correlates of developmental exposure to Mn andAs, particularly as a mixture.
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TL;DR: Several antioxidants including NAC, zinc, methionine, and cysteine, when used in conjunction with standard chelating agents, can improve the mobilization and excretion of arsenic and cadmium.
Journal ArticleDOI
The effects of arsenic exposure on the nervous system.
TL;DR: What is presently known about the effects of arsenic compounds on the nervous system in humans and rodents is described and its possible mechanisms of action are discussed.
Journal ArticleDOI
The developmental neurotoxicity of arsenic: cognitive and behavioral consequences of early life exposure.
TL;DR: The published literature indicates that arsenic is a human developmental neurotoxicant, and 15 epidemiological studies indicate that early life exposure is associated with deficits in intelligence and memory.
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Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity.
TL;DR: In this article, the authors used NAC, zinc, methionine, and cysteine in conjunction with standard chelating agents to improve the mobilization and excretion of arsenic and cadmium.