Open AccessJournal Article
Effects of Dietary Fat and Dose Level of 7,12-Dimethylbenz(α)-anthracene on Mammary Tumor Incidence in Rats
K. K. Carroll,H. T. Khor +1 more
TLDR
The type of diet fed after administration of 7,12-dimethylbenz(α)anthracene had a greater influence on mammary tumor incidence than did the type fed before the carcinogen was given, indicating that the effect is exerted mainly at the promotional stage of mammary carcinogenesis.Abstract:
Summary Female Sprague-Dawley rats maintained on a semisynthetic diet containing 20% corn oil developed more mammary tumors after treatment with a single p.o. dose of 7,12-dimethylbenz(α)anthracene than rats treated similarly but fed a low-fat semisynthetic diet. The tumor yield varied with the dose of 7,12-dimethylbenz(α)anthracene, but the rats on high-fat diet developed more tumors at each of 3 dose levels tested. The type of diet fed after administration of 7,12-dimethylbenz(α)anthracene had a greater influence on mammary tumor incidence than did the type fed before the carcinogen was given, indicating that the effect is exerted mainly at the promotional stage of mammary carcinogenesis.read more
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Prolactin and Murine Mammary Tumorigenesis: A Review
TL;DR: If prolactin can be shown to influence human breast epithelium in a manner similar to its effect on rodent mammary tissue, then prophylactic and/of chemotherapeutic control of human breast tumorigenesis may be feasible by appropriate drug-mediated Prolactin suppression.
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Estrogen Excretion Patterns and Plasma Levels in Vegetarian and Omnivorous Women
Barry R. Goldin,Herman Adlercreutz,Sherwood L. Gorbach,James H. Warram,Johanna T. Dwyer,Linda Swenson,Margo N. Woods +6 more
TL;DR: It is concluded that vegetarian women have an increase fecal output, which leads to increased fecal excretion of estrogen and a decreased plasma concentration of estrogen.
Journal ArticleDOI
Effects of level and type of dietary fat on incidence of mammary tumors induced in female sprague-dawley rats by 7,12-dimethylbenz(α) anthracene
Kenneth K. Carroll,H. T. Khor +1 more
TL;DR: Experiments indicated that unsaturated fats enhance the yield of adenocarcinomas more than saturated fats, and the possible relevance of these findings to the incidence of breast cancer in humans is discussed.
Journal Article
Analysis of Dietary Fat, Calories, Body Weight, and the Development of Mammary Tumors in Rats and Mice: A Review
TL;DR: The collection of animal experimental data supports the hypothesis that, in mammary tumor development, there is a specific enhancing effect of dietary fat, as well as a general enhances effect of calories.
References
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Journal ArticleDOI
A new, quantitative, approach to the study of the stages of chemical cartinogenesis in the mouse's skin.
I Berenblum,P Shubik +1 more
TL;DR: A New, Quantitative, Approach to the Study of the Stages of Chemical Carcinogenesis in the Mouse's Skin and its Applications is presented.
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Dietary factors associated with death-rates from certain neoplasms in man.
Journal Article
The Genesis and Growth of Tumors: IV. Effects of Varying the Proportion of Protein (Casein) in the Diet
TL;DR: It is concluded that varying the proportion of protein (casein) in the diet, within limits that permit relatively good body growth, probably has little effect on the formation of many types of tumors, but may have a significant effect upon certain special classes.
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Effects of level and type of dietary fat on incidence of mammary tumors induced in female sprague-dawley rats by 7,12-dimethylbenz(α) anthracene
Kenneth K. Carroll,H. T. Khor +1 more