Journal ArticleDOI
Effects of equinatoxin on the guinea-pig atrium
TLDR
The results suggest that the cardiac inhibitory effect of equinatoxin is mainly due to release of adenyl compounds, while the cardiac stimulant effect of the toxin may result from the liberation of arachidonic acid and subsequent formation of prostaglandins in the guinea-pig atrium.About:
This article is published in Toxicon.The article was published on 1987-01-01. It has received 34 citations till now. The article focuses on the topics: Cardiac stimulant & Tachyphylaxis.read more
Citations
More filters
Journal ArticleDOI
Cytolytic peptide and protein toxins from sea anemones (Anthozoa: Actiniaria).
Gregor Anderluh,Peter Maček +1 more
TL;DR: The crystal structure of equinatoxin II has been determined at 1.9A resolution, and biological, structure-function, and pharmacological characteristics of these cytolysins are reviewed.
Journal ArticleDOI
Pore formation by the sea anemone cytolysin equinatoxin II in red blood cells and model lipid membranes.
TL;DR: It was inferred that EqT-II increases membrane permeability by forming oligomeric channels comprising several copies of the cytolysin monomer, indicating the formation of cation-selective channels.
Journal ArticleDOI
Mechanism of action of equinatoxin II, a cytolysin from the sea anemone Actinia equina L. belonging to the family of actinoporins
TL;DR: Actinia equina equinatoxin II (EqT-II) is a representative of a family of pore-forming, basic, polypeptide toxins from sea anemones, now called actinoporins, which is active against a variety of mammalian cells including leukocytes, platelets and cardiomiocytes.
Journal ArticleDOI
Polypeptide cytolytic toxins from sea anemones (Actiniaria)
TL;DR: Putative biological roles of toxins, based on their channel-forming activity, in the capture and killing of prey, digestion, repelling of predators and intraspecific spatial competition are suggested.
Journal ArticleDOI
Primary and secondary structure of a pore-forming toxin from the sea anemone, Actinia equina L., and its association with lipid vesicles
Giovanna Belmonte,Gianfranco Menestrina,Cecilia Pederzolli,Igor Krizaj,Franc Gubenšek,Tom Turk,Peter Maček +6 more
TL;DR: It is proposed that at least part of the alpha-helix content increase of equinatoxin II is due to the insertion of its N-terminus into the lipid bilayer, which shares structural homology with membrane active peptides like melittin and viral fusion peptides.
References
More filters
Journal ArticleDOI
The importance of phospholipase-A2 in prostaglandin biosynthesis
Roderick J. Flower,Blackwell Gj +1 more
TL;DR: Phospholipase is the key enzyme which mobilises free fatty acids for prostaglandin biosynthesis during these types of cell injury, indicating that substrate availability is not the only requirement for stimulation of prostaglanders biosynthesis.
Journal ArticleDOI
Firefly luminescence in the study of energy transfer mechanisms. I. Substrate and enzyme determination.
TL;DR: Preliminary examination of certain biological processes with the Farrand photofluorometer suggests its wide applicability for routine surveys of phosphorylative energetic mechanisms.
Journal ArticleDOI
The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.
TL;DR: The data indicate the existence of a quinacrine-insensitive phospholipase C which can initially convert a given amount of PI to PA and which is closely associated to the thrombin receptor.
Journal ArticleDOI
8-Phenyltheophylline: A potent P1-purinoceptor antagonist
TL;DR: It is concluded that 8-phenyltheophylline is a more potent P1-purinoceptor antagonist than theophylla in antagonizing the inhibitory effects of adenosine in guinea-pig driven left atrium, rabbit basilar artery and electrically stimulated guinea -pig ileum preparations.
Journal ArticleDOI
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets☆
TL;DR: Two inhibitors of thrombin-stimulated arachidonic acid release from platelets, p-bromophenacyl bromide and mepacrine, were examined for their ability to inhibit the phosphatidylinositol-specific phospholipase C-diglyceride lipase pathway.
Related Papers (5)
Isolation and characterization of three lethal and hemolytic toxins from the sea anemone Actinia equina L.
Peter Maček,Drago Lebez +1 more
Cytotoxicity of equinatoxin II from the sea anemone Actinia equina involves ion channel formation and an increase in intracellular calcium activity.
Equinatoxin, a lethal protein from Actinia equina—I Purification and characterization
I. Ferlan,D. Lebez +1 more