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Journal ArticleDOI
Genetic Control of Host Responses to Endotoxin
TL;DR: Two pathophysiological effects of endotoxin in mice have been shown to be under the major influence of polygenic inheritance and the intraperitoneal extravascular leukocyte response to small doses of endotoxemia also was found to follow characteristic patterns ofPolygenic inheritance.
Book ChapterDOI
Genetic Determinants of Immunological Responsiveness
TL;DR: The immune response to a very large number of antigens is under some type of genetic control, and an excellent example of this principle is the response of mice to lysozyme.
Journal ArticleDOI
Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cells.
Ron N. Apte,Dov H. Pluznik +1 more
TL;DR: The results suggest that CSF may play a physiologic role in vivo as a granulopoietin and it was shown that the genetic control mechanisms governing the CSF/CFC responses are determined by the lipid A‐KDO portion of the LPS molecule, suggesting that lipid A is the active part of theLPS molecule in stimulating granulipoiesis.
Journal ArticleDOI
Repair of thermal brain injury in laboratory rodents.
TL;DR: Large zones of coagulation necrosis were produced in the cerebral hemispheres of rodents by burning the intact skull, and rats, gerbils, and hamsters responded more rapidly and with far more macrophages.
Journal ArticleDOI
Colonization history shaped the immunity of the western house mouse
TL;DR: The results indicate that founder events in European mice and selection pressure exerted by the composition of local parasitic helminth communities underlie the observed patterns.
Related Papers (5)
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