Journal ArticleDOI
Gentamicin sulfate distribution in body fluids
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TLDR
The intravenous administration of gentamicin was well tolerated and no unexpected toxicity was observed and the drug did not diffuse readily into the cerebrospinal fluid.Abstract:
Pharmacological studies were conducted on patients receiving gentamicin sulfate intravenously. The mean peak serum level was 4.5 P,g per milliliter after the administration of 40 mg. per square meter gentamicin sulfate. The serum half‐life was approximately 2 hours and the decrease was exponential. There was no evidence of drug accumulation when administered at a dose of 30 mg. per square meter every 6 hours over a 10 day period. The concentration of gentamicin in thoracic duct lymph paralleled the simultaneous serum concentration. The drug did not diffuse readily into the cerebrospinal fluid. The intravenous administration of gentamicin was well tolerated and no unexpected toxicity was observed.read more
Citations
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Gentamicin Serum Concentrations: Pharmacokinetic Predictions
Hull Jh,Sarubbi Fa +1 more
TL;DR: A digital method to evaluate the accuracy of commonly used dosing nomograms based on the uncertainty of gentamicin serum concentrations has been developed.
Journal ArticleDOI
Pharmacokinetics of Gentamicin in Children and Adults
TL;DR: Age markedly affected the peak concentrations: a 1-mg/kg dose produced mean peak concentrations of 1.58, 2.03, and 2.81 mug/ml in the one-half to five, five to 10, and greater than 10 year age groups, respectively; this age-related change in dose response was diminished when the dose was calculated on the basis of body surface area.
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Cancer chemotherapy by infusion
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Journal ArticleDOI
Drug kinetics and artificial kidneys.
TL;DR: The factors affecting solute movement across the membrane during haemodialysis are well understood but studies of the effects of artificial kidneys on drug kinetics have often been limited by a lack of attention to proper methods of calculating solute clearance by the artificial kidney.
Journal ArticleDOI
Treatment of Gram-Negative Bacillary Meningitis in Adults
TL;DR: Among adults, Gram-negative bacillary meningitis (excluding that due to Hemophilus influenzae) is most frequently associated with chronic systemic disease or invasive procedures of the cent...
References
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Journal ArticleDOI
Gentamicin, a new antibiotic complex from micromonospora.
Marvin J. Weinstein,George M Luedemann,E. M. Oden,Gerald H. Wagman,Jean Pierre Rosselet,Joseph A. Marquez,Carmine T. Coniglio,William Charney,Hershel L. Herzog,Jack Black +9 more
Journal ArticleDOI
The importance of underlying disease in patients with gram-negative bacteremia.
Marvin A. Freid,Kenneth L. Vosti +1 more
TL;DR: A significantly lower fatality ratio was found only among patients who received appropriate as contrasted with inappropriate antimicrobial treatment in the nonfatal category and no significant differences in fatality ratios were found among patients in comparable categories of underlying disease.
Journal Article
Pharmacology of gentamicin, a new broad-spectrum antibiotic.
Journal ArticleDOI
Laboratory and clinical studies of gentamicin, a new broad-spectrum antibiotic.
Journal ArticleDOI
Recent Microbiological Studies with Gentamicin
TL;DR: Initial studies demonstrated that the 3 components of gentamicin have nearly identical in vitro activity and showed that the acute toxicity as well as the protective activity of the3 components against Staphylococcus aureus were not significantly different in mice.