Journal ArticleDOI
Histamine release by neuromuscular blocking agents in man.
Jonathan Moss,Jonathan Moss,Daniel M. Philbin,Carl E. Rosow,S. J. Basta,C. Gelb,John J. Savarese +6 more
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TLDR
The data obtained in humans can be shown to validate the cat model as a means of screening novel neuromuscular blocking agents and to suggest that members of this class of drugs can cause a dose dependent release histamine release in man.Abstract:
Several experimental and clinical studies have suggested that histamine is released following the administration of neuromuscular blocking agents, and that the histamine release is an important aspect in the hemodynamic response to the drug. We have measured plasma histamine following the administration of a series of neuromuscular blocking agents in man. Our data suggests that members of this class of drugs can cause a dose dependent release histamine release in man and that this release is hemodynamically significant. We have also evaluated the roles of rate of administration, of pretreatment with H1 and H2 antagonists and alterations in drug design as clinical strategies in attenuating the adverse reactions. The data obtained in humans can be shown to validate the cat model as a means of screening novel neuromuscular blocking agents.read more
Citations
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Journal ArticleDOI
Histamine and cardiac arrhythmias.
Andrew A. Wolff,Roberto Levi +1 more
TL;DR: The ability to record transmembrane action potenrial(s) (TAP) from single cells has permitted the study of electrophysiological mechanisms underlying histamine-induced arrhythmias.
Journal ArticleDOI
Atracurium: clinical strategies for preventing histamine release and attenuating the haemodynamic response
R. P. F. Scott,John J. Savarese,S. J. Basta,N. Sunder,Hassan H. Ali,M. Gargarian,M. Gionfriddo,A. G. Batson +7 more
TL;DR: The rapid (5-s) bolus dose of atracurium i.v. resulted in a significant increase in plasma histamine concentration (P less than 0.05) and was associated with a decrease in mean arterial pressure and an increase in heart rate, and administration of the same dose slowly prevented the increase, and abolished the subsequent haemodynamic response.
Book ChapterDOI
Neuromuscular-blocking agents
Jerrold B. Leikin,Frank Paloucek +1 more
TL;DR: This policy contains information which is clinical in nature and is used by Wellmark to make determinations whether medical treatment is covered under the terms of a Wellmark member's health benefit plan.
Journal ArticleDOI
Adverse effects of neuromuscular blockers and their antagonists.
TL;DR: Among all the drugs used for general anaesthesia, neuromuscular blockers appear to play a prominent role in the incidence of severe adverse reactions as mentioned in this paper, and it now seems likely that most serious adverse drug reactions occurring during anaesthesia are immunological in type.
Journal ArticleDOI
Perioperative uses of histamine antagonists.
TL;DR: The authors recommend that this prophylaxis be given to the following groups of patients: those with a history of adverse reactions or history of allergy, patients undergoing surgery with a high risk of histamine release, elderly patients, and those with poor physical status due to underlying systemic diseases.
References
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Journal ArticleDOI
Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.
TL;DR: The use of rat kidney instead of guinea pig brain as the source of histamine- N -methyltransferase for the enzymatic assay of histamines was found to improve the sensitivity of the assay.
Journal ArticleDOI
The pharmacology of atracurium: a new competitive neuromuscular blocking agent
R. Hughes,D.J. Chapple +1 more
TL;DR: In vitro studies have shown that the non-enzymic decomposition of atracurium by "Hofmann Elimination" was enhanced by increasing pH, and in vivo neuromuscular paralysis was significantly reduced when the arterial pH was increased.
Journal ArticleDOI
Evaluation of atracurium in anaesthetized man
J.P. Payne,R. Hughes +1 more
TL;DR: The course of action of atracurium was appreciably shorter than that of other recognized competitive blocking agents and provided adequate relaxation during surgical intervention for 15--45 min; spontaneous recovery without the use of neostigmine was observed in some patients.
Journal ArticleDOI
Clinical Pharmacology of ORG NC45 (NorcuronTM): A New Nondepolarizing Muscle Relaxant
Mark R. Fahey,Robert B. Morris,Ronald D. Miller,Y. J. Sohn,Roy Cronnelly,Peter J. Gencarelli +5 more
TL;DR: It was concluded that ORG NC45 is more potent and has a shorter duration of action with both initial and repetitive doses than does pancuronium, with these characteristics and the reported lack of cardiovascular effects.