Journal ArticleDOI
Hyperphagia in Rats with Cuts between the Ventromedial and Lateral Hypothalamus
D. J. Albert,L. H. Storlien +1 more
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Bilateral cuts between the ventromedial and lateral hypothalamus in female rats consistently produced hyperphagia, which is consistent with other evidence that suggests that fibers originating medially stop eating by inhibiting cells in theateral hypothalamus.Abstract:
Bilateral cuts between the ventromedial and lateral hypothalamus in female rats consistently produced hyperphagia. Hyperphagia occurred slightly less reliably when one of the cuts entered the ventromedial hypothalamus and only infrequently if one entered the lateral hypothalamus. The results are consistent with other evidence that suggests that fibers originating medially stop eating by inhibiting cells in the lateral hypothalamus.read more
Citations
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The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight.
TL;DR: Lesion studies with weanling rats and adult pair-tube-fed rats, as well as recent studies of knockout mice deficient in the orphan nuclear receptor steroidogenic factor 1, indicate that VMH lesion-induced obesity is in large part a metabolic obesity (due to autonomic nervous system disorders) independent of hyperphagia.
Journal ArticleDOI
The physiological psychology of hunger: a physiological perspective.
TL;DR: It is proposed that the stimulus for hunger derives from information provided to the brain by the liver in the course of normal hepatic function, and may be associated with an alteration in oxidative metabolism within the liver, with food intake reversing that change.
Journal ArticleDOI
Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine.
TL;DR: Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats.
Journal ArticleDOI
The organization of the ventromedial hypothalamic nucleus.
TL;DR: The ventromedial hypothalamic nucleus has been studied in mature mouse and rat brains with the rapid Golgi method and HVM dendrites are long and generally unramified and bear a number of spinous processes.
References
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Journal ArticleDOI
The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions.
Journal ArticleDOI
Reciprocal Activities of the Ventromedial and Lateral Hypothalamic Areas of Cats
TL;DR: The concept that glucose-sensitive neurons are present in the ventromedial nucleus was supported by the effects on the spontaneous unit discharges of injecting glucose and other-solutions intravenously.
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The VMH: A center for affective reactions, satiety, or both?
TL;DR: The classical VMH-lesion effect on food intake and/or the paradoxical lowering of food-rewarded instrumental behavior may be due to an interference with affective rather than appetitive mechanisms.
Journal ArticleDOI
Anatomical connections between medial and lateral regions of the hypothalamus concerned with food intake.
Edward A. Arees,Jean Mayer +1 more
TL;DR: No anatomical connections have yet been demonstrated from the ventromedial ("satiety") to the lateral ("feeding") areas of the hypothalamus, but fiber connections between these two areas were demonstrated.
Journal ArticleDOI
Relationship between feeding and satiation centers of the hypothalamus.
W. Wyrwicka,Czeslawa Dobrzecka +1 more
TL;DR: Electrodes were implanted in the hypothalamus of five goats in which an alimentary instrumental conditioned reflex had been previously established and withdrawal of the stimulation of the medial hypothalamus evoked a short aftereffect in the form of a recovery or increase in the trained movements and food intake.