Book ChapterDOI
Immune Complex Disease in Experimental Animals and Man
Charles G. Cochrane,D Koffler +1 more
TLDR
This chapter summarizes the data presented in two reviews of experimental acute and chronic immune complex disease produced by nonliving antigens and discusses in detail more recent studies.Abstract:
Publisher Summary No experimental model has provided greater insight into the mechanism of immune complex disease than the experimental serum sickness. The morphological, immunohistological, and serological features of the laboratory models have provided a basis for understanding the pathogenic mechanisms responsible for human glomerulonephritis, vasculitis, and a variety of systemic connective tissue diseases. The subject of experimental acute and chronic immune complex disease produced by nonliving antigens has received extensive review in this series. This chapter summarizes the data presented in these two reviews and discusses in detail more recent studies. Experiments to study acute immune complex disease (serum sickness) have been performed in rabbits almost exclusively. Experimental chronic immune complex disease has proved to be a most useful model in understanding human glomerulonephritis. When injected daily with heterologous serum protein antigens, rabbits with strong antibody responses develop chronic membranous glomerulonephritis in about 5 weeks.read more
Citations
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Journal ArticleDOI
The Spectrum of Vasculitis: Clinical, Pathologic, Immunologic, and Therapeutic Considerations
TL;DR: In recent years, several of the more serious vasculitides, such as Wegener's granulomatosis and the systemic necrotizing vascultides of the polyarteritis nodosa group, have been shown to be extraordinarily responsive to chronic low-dose cytotoxic therapy, particularly cyclophosphamide.
Journal ArticleDOI
Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients.
Peter D. Gorevic,Hannah Jane Kassab,Yoram Levo,Robert W. Kohn,Martin Meltzer,Philip Prose,Edward C. Franklin +6 more
TL;DR: Follow-up for periods up to 21 years from onset of symptoms revealed that renal involvement has a deleterious effect on prognosis.
Journal ArticleDOI
The Raji cell radioimmune assay for detecting immune complexes in human sera.
TL;DR: A sensitivie and simple procedure for the detection and quantitation of soluble complement (C)- fixing immune complexes in sera of patients with various disease states has been developed by utilizing C receptors on Raji cells.
Journal ArticleDOI
Normal and abnormal aspects of proteinuria: Part I: Mechanisms, characteristics and analyses of urinary protein. Part II: Clinical considerations
E.P. Lillehoj,M.D. Poulik +1 more
TL;DR: In this article, the authors highlight the mechanisms of glomerular filtration and tubular reabsorption of plasma proteins, selected characteristics of urinary proteins based upon electrophoretic properties and recent advances in clinical laboratory analysis of proteinuria.
References
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Journal ArticleDOI
STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study
Guido Majno,G. E. Palade +1 more
TL;DR: The mechanism, whereby histamine and serotonin increase the permeability of blood vessels, was studied in the rat by means of the electron microscope, and electron microscopic findings suggested that the endothelial cells become partially disconnected along the intercellular junctions.
Journal ArticleDOI
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.
TL;DR: Most qualitative and quantitative antibody tests measure secondary effects of primary antigen-antibody interactions, but they do not always reflect the total antibody content of the antiserum with respect to the test antigen.
Journal ArticleDOI
Immunological studies concerning the nephritis of systemic lupus erythematosus
TL;DR: The immunochemical evidence for the high specific activity of antinuclear antibodies and the association of DNA antigen with DNA antibody in glomeruli add further support for the antigen-antibody complex hypothesis for renal injury in systemic lupus erythematosus.