Journal ArticleDOI
Is Australia ready for fentanyl
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This article is published in Science & Justice.The article was published on 2018-05-01. It has received 9 citations till now.read more
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The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies.
TL;DR: Because social, economic, and health problems related to the use of fentanyl and its analogs are growing, there is an urgent need to implement large-scale safe and effective harm reduction strategies to prevent fentanyl-related overdoses.
Journal ArticleDOI
The opioid mortality epidemic in North America: do we understand the supply side dynamics of this unprecedented crisis?
TL;DR: Improved analyses and understanding of the supply-side dynamics of the opioid crisis are urgently needed in order to inform future intervention and policy development.
Journal ArticleDOI
Analyzing fentanyl and fentanyl analogues by ion mobility spectrometry
TL;DR: The results showed that the COTS IMS was capable of detecting the presence of programmed fentanyl-related substances and unprogrammed fentanyl- related substances were detected, however no alarm was generated and the information was accessible via the advanced user mode only.
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Urine drug screening for early detection of unwitting use of fentanyl and its analogues among people who inject heroin in Sydney, Australia.
Monica J. Barratt,Monica J. Barratt,Monica J. Barratt,Julie Latimer,Marianne Jauncey,Emma My Tay,Suzanne Nielsen +6 more
TL;DR: While no cases of fentanyl-laced heroin use have been detected so far, this pilot study has demonstrated that this surveillance design is low-cost, feasible and scalable approach to monitoring the considerable public-health threat of undetected fentanyl and its analogues in Australia.
Journal ArticleDOI
The relative lethal toxicity of pharmaceutical and illicit substances: A 16-year study of the Greater Newcastle Hunter Area, Australia.
Jonathan Brett,Jonathan Brett,Claire E. Wylie,Jacques Raubenheimer,Geoff Isbister,Nicholas A. Buckley,Nicholas A. Buckley +6 more
TL;DR: This work aims to calculate 2 metrics of relative lethal toxicity; the fatal toxicity index (FTI) and the case fatality (CF) with a focus on opioids, antidepressants, antipsychotics, benzodiazepines and illicit drugs.
References
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Journal ArticleDOI
The Fentanyl Story
TL;DR: The data indicate that fentanyl's popularity has occurred because it has minimal cardiovascular effects, does not result in increases in plasma histamine, is relatively short in onset of action and duration of effect, is easy and inexpensive to synthesize and prepare for the marketplace, and is now familiar to clinicians working in pain and perioperative medicine throughout the world.
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Analysis of clothing and urine from Moscow theatre siege casualties reveals carfentanil and remifentanil use.
TL;DR: Evidence is provided from liquid chromatography-tandem mass spectrometry analysis of extracts of clothing from two British survivors, and urine from a third survivor, that the aerosol comprised a mixture of two anaesthetics--carfentanil and remifetanil--whose relative proportions this study was unable to identify.
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Designer drugs: past history and future prospects.
TL;DR: It is likely that, as efforts to restrict the importation of natural products and prevent diversion of pharmaceuticals become more effective, the fentanyls and other synthetics will become increasingly important drugs of abuse.
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Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe
TL;DR: Investigation from Estonia identified that in the European context, fentanyls are 'low use but high risk/harm' substances, and evidence shows that Estonia stands out as having an endemic problem, while the use of fENTanyls in other European countries appears to be geographically localised.
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Fentanyl-related deaths: demographics, circumstances, and toxicology of 112 cases.
TL;DR: Although most of the fentanyl victims had a prior history of intravenous drug use, morphine or codeine were not commonly found, which suggests that the victims had little or no opiate tolerance.