Journal ArticleDOI
Late-onset psychosis and risedronate treatment for osteoporosis.
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TLDR
The case of M, age 59, who was treated with risedronate for osteoporosis, and was subsequently diagnosed with atypical psychosis after other organic causes were excluded, suggests that the risedonate might have triggered a psychotic reaction that resolved following cessation of treatment.Abstract:
As women age and enter menopause, they are sometimes more susceptible than men to certain physical and mental disorders such as osteoporosis and late-onset schizophrenia. Risedronate (Actonel©) is a bisphosphonate used for the treatment of osteopenia. Early initiation of pharmacotherapy for osteopenia is recommended to prevent greater bone loss. The most common side effects of risedronate include fever and flu-like symptoms, hypocalcemia, bone and joint pain, peripheral edema, fatigue, change in bowel movements, osteonecrosis of the jaw, and atrial fibrillation. Though reports in the professional literature of psychotic reactions to risedronate are scant, there have been FDA reports as well as patient discussions of psychiatric side effects from this medication on popular websites. We report the case of M, age 59, who was treated with risedronate for osteoporosis, and was subsequently diagnosed with atypical psychosis after other organic causes were excluded. Though it is conceivable that age-related psychosocial and physical factors triggered late-onset schizophrenia, the temporal relationship between the termination of treatment with risedronate and the improvement in her mental state suggests that the risedronate might have triggered a psychotic reaction that resolved following cessation of treatment.read more
Citations
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Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records.
Yanshan Wang,Yiqing Zhao,Terry M. Therneau,Elizabeth J. Atkinson,Ahmad P. Tafti,Nan Zhang,Shreyasee Amin,Andrew H. Limper,Sundeep Khosla,Hongfang Liu +9 more
TL;DR: Experimental results show that the proposed Poisson Dirichlet Model (PDM) could effectively identify distinguished disease clusters based on the latent patterns hidden in the EHR data by alleviating the impact of age and sex, and that LDA could stratify patients into more differentiable subgroups than PDM in terms of p-values.
Journal ArticleDOI
Peri- and Post-Menopausal Women with Schizophrenia and Related Disorders Are a Population with Specific Needs: A Narrative Review of Current Theories
TL;DR: In this article, the potential role of menopause in changing drug efficacy and clinical outcome in schizophrenia related disorders has been understudied, and the relevant literature to test whether optimizing menopausal and postmenopausal treatment and addressing specific health needs of this stage in life will improve outcome.
Posted Content
Unsupervised Machine Learning for the Discovery of Latent Disease Clusters and Patient Subgroups Using Electronic Health Records
Yanshan Wang,Yiqing Zhao,Terry M. Therneau,Elizabeth J. Atkinson,Ahmad P. Tafti,Nan Zhang,Shreyasee Amin,Andrew H. Limper,Hongfang Liu +8 more
TL;DR: In this paper, the authors investigated the application of unsupervised machine learning models in discovering latent disease clusters and patient subgroups based on EHRs and proposed a novel model named Poisson Dirichlet Model (PDM), which extends the LDA approach using a Poisson distribution to model patients' disease diagnoses and to alleviate age and sex factors by considering both observed and expected observations.
References
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Late-Onset Schizophrenia and Very-Late-Onset Schizophrenia-Like Psychosis: An International Consensus
TL;DR: The authors conducted a MEDLINE literature review and developed a consensus statement summarizing the findings from 2 days of debate and discussion by members of the International Late-Onset Schizophrenia Group, achieving consensus on diagnosis, nomenclature, treatment guidelines, and treatment guidelines.
Journal ArticleDOI
Osteoporosis: epidemiology, diagnosis, and treatment.
TL;DR: With a few preventive measures such as identification of risk factors, careful examination, and a few simple diagnostic tests, prevention of osteoporosis during the teen and early adult years is far superior to any treatment for older individuals.
Journal ArticleDOI
Late-onset schizophrenia and very late-onset schizophrenia-like psychosis
TL;DR: The diagnoses of late-onset schizophrenia and very-late-onset schizophrenia-like psychosis have face validity and clinical utility and general adoption of these categories will foster systematic investigation of such patients.
Journal ArticleDOI
Prevalence and related risk factors of osteoporosis in peri- and postmenopausal Indian women
Neelam Aggarwal,Ainharan Raveendran,Niranjan Khandelwal,Ramesh Kumar Sen,J S Thakur,Lakhbir Kaur Dhaliwal,Veenu Singla,Sakthivel Rajan Rajaram Manoharan +7 more
TL;DR: The findings from the study suggest the need for large community-based studies so that high-risk population can be picked up and early interventions and other life style changes can be instituted if there is delay in implementing national or international health strategies to tackle this increasing global health problem.
Journal ArticleDOI
Menopause and schizophrenia.
TL;DR: The importance of a clear understanding of this phase of life in patients suffering from or who present with a risk of developing schizophrenia is highlighted, as well as the hypothesis of hormone replacement therapy providing benefits in the management of these disorders in menopausal women.