Book ChapterDOI
Magnetic Fluid Hyperthermia (MFH)
A. Jordan,Peter Wust,R. Scholz,H. Faehling,J. Krause,R. Felix +5 more
- pp 569-595
TLDR
In this article, a short review is given on current conventional hyperthermia technology, including the use of Magnetic Resonance Imaging (MRI) for treatment planning, advancements of AC magnetic field applicator technology, and options for magnetic fluid conjugates with isotopes and drugs.Abstract:
A short review is given on current conventional hyperthermia technology. As an alternative, heat can also be generated by a magnetic fluid, which is excited by an externally applied AC magnetic field. In contrast to regional Radiofrequency (RF-) systems, Magnetic Fluid Hyperthermia (MFH) is not limited by electric (E-)field boundary effects and heterogeneous tissue conductivity. MFH may become interesting especially for tumors which currently cannot, or only with highly invasive procedures, be treated with hyperthermia, e.g. bone tumors, intrathoracal tumors, tumors of the base of the scull and of the brain. Current physical and biological results of MFH with carcinoma cells in vitro and experimental tumors in vivo are presented. Deeper insights into the mechanism of magnetic fluid power absorption, the use of Magnetic Resonance Imaging (MRI) for treatment planning, advancements of AC magnetic field applicator technology, intracellular hyperthermia, and options for magnetic fluid conjugates with isotopes and drugs are tasks for future research.read more
Citations
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Electromagnetic Activation of Shape Memory Polymer Networks Containing Magnetic Nanoparticles
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Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer
TL;DR: The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies.
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Magnetic nanoparticle hyperthermia for prostate cancer
TL;DR: Until these limitations are overcome and thermoablation can safely be applied as a monotherapy, this treatment modality is being evaluated in combination with irradiation in patients with localised prostate cancer.
Journal ArticleDOI
Effects of Magnetic Fluid Hyperthermia (MFH) on C3H mammary carcinoma in vivo
Andreas Jordan,Regina Scholz,Peter Wust,H. Fähling,J. Krause,W. Wlodarczyk,B. Sander,Th. Vogl,Roland Felix +8 more
TL;DR: Encouraging results have been obtained, which show that one single high dose MFH is already able to induce local tumour control in many cases within 30 days after treatment, and this most probably reflected the critical problem of homogeneity of the intratumoural MF distribution.
References
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