Journal ArticleDOI
Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model
Daniel Boon Loong Teh,Soo Min Chua,Ankshita Prasad,Ioannis Kakkos,Wenxuan Jiang,Mu Yue,Xiaogang Liu,Angelo H. All,Angelo H. All +8 more
TLDR
Early local moderate hypothermia can be induced for extended periods of time post SCI in the rodent model and improves functional electrophysiological outcome and motor behavior recovery for a long time, lasting until 8 weeks.About:
This article is published in The Spine Journal.The article was published on 2017-10-01. It has received 14 citations till now. The article focuses on the topics: Hypothermia & Spinal cord injury.read more
Citations
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Journal ArticleDOI
A Review of Functional Electrical Stimulation Treatment in Spinal Cord Injury
TL;DR: Overall, FES can be used to improve respiration, circulation, hand strength, mobility, and metabolism after SCI, highlighting upper and lower extremity strength, cardiopulmonary function, and balder control.
Journal ArticleDOI
Hypothermia Therapy for Traumatic Spinal Cord Injury: An Updated Review
Seth C Ransom,Nolan J. Brown,Zach Pennington,Nikita Lakomkin,Anthony L. Mikula,Mohamad Bydon,Benjamin Elder +6 more
TL;DR: These limited clinical trials show promise and suggest therapeutic hypothermia to be safe in TSCI patients, though its effect on neurological recovery remains unclear, and the preclinical literature supports the efficacy of hypthermia after TSCi.
Journal ArticleDOI
Hypothermic treatment after computer‑controlled compression in minipig: A preliminary report on the effect of epidural vs. direct spinal cord cooling
Monika Závodská,Ján Gálik,Martin Marsala,Stefania Papcunova,Jaroslav Pavel,Enikö Račeková,Marcela Martončíková,Igor Šulla,Miroslav Gajdoš,Imrich Lukáč,Jozef Kafka,Valent Ledecky,Peter Reichel,Alexandra Trbolova,Igor Capik,Katarina Bimbova,Maria Bacova,Andrea Stropkovska,Alexandra Kisucká,Dana Miklisová,Nadezda Lukacova +20 more
TL;DR: Investigation of therapeutic efficacy of local hypothermia on tissue preservation along the rostro-caudal axis of the spinal cord and the prevention of injury-induced functional loss in a newly developed computer-controlled compression model in minipig suggests that clinically-proven medical treatments for SCI combined with early 5 h-long salinehypothermia treatment without opening the dural sac could be more beneficial for tissue preservation and neurological outcome.
Journal ArticleDOI
Hypothermia in the course of acute traumatic spinal cord injury.
Jozef Kafka,Jozef Kafka,Nadezda Lukacova,Igor Sulla,Marcela Maloveska,Zuzana Vikartovska,Dasa Cizkova +6 more
TL;DR: In various animal studies, hypothermic treatment applied in the acute phase after SCI has resulted in neuroprotective effects, most likely due to inhibition of blood flow and oxygen consumption and reduction of overall metabolic activity and inflammation, resulting in improved nerve tissue sparing.
Early General Hypothermia Improves Motor Function after Spinal Cord Injury in Rats; a Systematic Review and Meta-Analysis.
Mahmoud Yousefifard,Mohammad Hossein Vazirizadeh-Mahabadi,Leila Haghani,Farhad Shokraneh,Alexander R. Vaccaro,Vafa Rahimi-Movaghar,Mostafa Hosseini +6 more
TL;DR: It is found that general hypothermia improves locomotion after SCI in rats and duration of induction and the target temperature are two essential considerations for general therapeutic Hypothermia.
References
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Journal ArticleDOI
Cooling for newborns with hypoxic ischaemic encephalopathy.
TL;DR: Although two small randomised controlled trials demonstrated neither evidence of benefit or harm, current evidence is inadequate to assess either safety or efficacy of therapeutic hypothermia in newborn infants with hypoxic ischaemic encephalopathy.
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Neuroprotective mechanisms of hypothermia in brain ischaemia
Midori A. Yenari,Hyung Soo Han +1 more
TL;DR: It is likely that no single factor can explain the neuroprotection provided by hypothermia, but understanding its myriad effects may shed light on important neuroprotective mechanisms.
Journal ArticleDOI
Hypothermia for acute brain injury—mechanisms and practical aspects
TL;DR: An overview of the potential neuroprotective mechanisms of hypothermia, practical considerations for the application of TTM, and disease-specific evidence for the use of this therapy in patients with acute brain injuries is provided.
Journal ArticleDOI
Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia.
TL;DR: Experimental data obtained in animal models of brain and SCI demonstrating the benefits of mild to moderate hypothermia are reviewed and critical data for the translation of this therapy to the clinical arena are provided.
Journal ArticleDOI
Therapeutic hypothermia for acute liver failure.
TL;DR: Although an ample body of experimental and human data provides a rationale for the use of therapeutic Hypothermia in patients with acute liver failure, multicenter, randomized, controlled clinical trials are needed to confirm that hypothermia secures brain viability and improves survival without causing harm.