Open AccessDOI
Nonfunctioning Pituitary Tumors
Mary H. Samuels
- pp 77-94
TLDR
Pituitary adenomas that do not secrete growth hormone, adrenocorticotropic hormone, prolactin, or thyroid-stimulating hormone constitute the nonfunctioning pituitary tumors.Abstract:
Pituitary adenomas are commonly divided into “functioning” tumors (those that secrete pituitary hormones and cause clinical syndromes) and “nonfunctioning” tumors (those that do not secrete a pituitary hormone that leads to a clinical syndrome) (1). Tumors that do not secrete growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin, or thyroid-stimulating hormone (TSH) constitute the nonfunctioning pituitary tumors. Approximately 30% of pituitary adenomas are considered nonfunctioning by these criteria.read more
Citations
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Journal Article
Anterior Pituitary Function in Patients with Nonfunctioning Pituitary Adenoma: Results of Longitudinal Follow-up.:Results of Longitudinal Follow-up
TL;DR: In this paper, the authors examined pituitary function longitudinally among three types of patients: those with complete tumor removal (group A), those with subtotal or partial adenomectomy (group B); and those in group B who underwent additional radiation therapy (group C).
References
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Journal ArticleDOI
Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency.
Beverly M. K. Biller,Mary H. Samuels,Anthony Zagar,David M. Cook,Baha M. Arafah,Vivien Bonert,Stavros S. Stavrou,David L. Kleinberg,John J. Chipman,Mark L. Hartman +9 more
TL;DR: The ARG plus GHRH test represents an excellent alternative to the ITT for the diagnosis of GH deficiency in adults and can be made without performing an ITT, provided that test-specific cut-points are used.
Journal ArticleDOI
Comparison of the Low Dose Short Synacthen Test (1 μg), the Conventional Dose Short Synacthen Test (250 μg), and the Insulin Tolerance Test for Assessment of the Hypothalamo-Pituitary-Adrenal Axis in Patients with Pituitary Disease
TL;DR: The results of this study indicate that both SST and LDSST, at a cortisol cut-off of 600 nmol/L, are safe for the purpose of clinical decision-making with regard to steroid replacement therapy in patients with pituitary disease.
Journal ArticleDOI
Reversible Hypopituitarism in Patients with Large Nonfunctioning Pituitary Adenomas
TL;DR: It is suggested that compression of the portal circulation is a possible mechanism for hypopituitarism in this setting and significant improvement in pituitsary function may occur after surgical adenomectomy for nonsecreting pituitary tumors.
Journal ArticleDOI
The Pituitary Incidentaloma
Mark E. Molitch,Eric J. Russell +1 more
TL;DR: Evidence related to sellar masses that might be found incidentally on various radiologic procedures, including their differential diagnosis and recommendations for their evaluation and treatment is reviewed, including pituitary adenomas found to be hypersecreting.
Journal ArticleDOI
Gonadotroph Cell Adenomas of the Pituitary
TL;DR: Both the clinical and hormonal characteristics of gonadotroph cell adenomas usually make them readily distinguishable from pituitary enlargement due to long-standing primary hypogonadism.