Patent
Nutritional supplement for cerebral metabolic insufficiencies
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TLDR
In this paper, a pharmaceutical composition which includes a sugar and a Krebs cycle intermediate, or salt thereof, or a precursor of a k-cycle intermediate is described, and the present invention relates to administration of the pharmaceutical composition to treat an individual for a disorder involving impaired mitochondrial function.Abstract:
The present invention relates to a pharmaceutical composition which includes a sugar and a Krebs cycle intermediate, or salt thereof, or a precursor of a Krebs cycle intermediate. Krebs cycle intermediates include citric acid, aconitic acid, isocitric acid, α-ketoglutaric, succinic acid, fumaric acid, malic acid, and oxaloacetic acid, and mixtures thereof. Precursors of Krebs cycle intermediates are compounds converted by the body to form a Krebs cycle intermediate. The present invention also relates to administration of the pharmaceutical composition to treat an individual for a disorder involving impaired mitochondrial function and to improve cerebral function in an individual having impaired cerebral metabolism.read more
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Journal ArticleDOI
The development of mitochondrial medicine.
TL;DR: The first myopathy was demonstrated only 35 years ago as discussed by the authors, and the list continues to grow, and the field's dramatic expansion reflects growth of knowledge in three areas: (i) characterization of mitochondrial structure and function, (ii) elucidation of the steps involved in mitochondrial biosynthesis, and (iii) discovery of specific mitochondrial DNA.
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