Journal ArticleDOI
On an ethical cum optimal adaptive allocation design
TLDR
In this paper, a two-treatment single period two-stage adaptive allocation design was proposed for achieving larger allocation proportion to the better treatment arm in the course of the trial with increased precision of the parameter estimator.Abstract:
In the present work, we formulate a two-treatment single period two-stage adaptive allocation design for achieving larger allocation proportion to the better treatment arm in the course of the trial with increased precision of the parameter estimator. We examine some properties of the proposed rule and compare it with some of the existing allocation rules and report substantial gain in efficiency with a considerably larger number of allocations to the better treatment even for moderate sample sizes.read more
Citations
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Journal ArticleDOI
A randomized two stage allocation for continuous response clinical trials
TL;DR: A randomized two treatment allocation design, conducted in two stages, is proposed for a class of continuous response trials and relevant properties of the proposed allocation design are investigated and compared with suitable competitors.
Journal ArticleDOI
Adaptive Allocation Designs for Normal and Binary Treatment Responses
TL;DR: A class of adaptive designs is formulated in two stages for clinical trials to favour the better performing treatment for further allocation in an efficient way and compare with the existing allocation designs.
Journal ArticleDOI
A multi-treatment two stage adaptive allocation for survival outcomes
TL;DR: In this paper, a multi-treatment two-stage adaptive allocation design for survival responses is developed for noninformative random censoring, asymptotic p values of relevant tests of equality of treatment effects are used to derive the assignment probability of incoming second stage subjects.
Journal ArticleDOI
A two-stage adaptive allocation design for survival outcome with informative censoring
TL;DR: In this article, an adaptive two-stage allocation design for survival responses subject to independent informative censoring is developed for survival response subject to adaptive censoring, where the asymptotic p value of a score test related to a hypothesis of treatment effectiveness is used to set the assignment probability of the second stage.
References
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Journal ArticleDOI
An adaptive randomized design with application to estimation
TL;DR: In this paper, a simple randomized adaptive design is proposed for estimating the difference between two success probabilities and the difference of two normal means, where the optimal proportion of the data that should be allocated to the first population, if it exists, often depends on unknown parameters.
Journal ArticleDOI
Some results on estimation for two—stage clinical trials
TL;DR: In this article, a two-stage clinical trial setting is considered in which two treatments are available for a particular ailment, and the exact bias and variance of the estimated treatment difference at the end of the trial are derived.
Journal ArticleDOI
An optimal sequential procedure in ethical allocation
TL;DR: In this article, a sequential allocation scheme for comparing two competing treatments in clinical trials is proposed, which is a compromise between ethical and optimum allocations. But the proposed scheme is limited to a fixed target sample size.
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