Journal ArticleDOI
Particles associated with Australia Antigen in the Sera of Patients with Leukaemia, Down's Syndrome and Hepatitis
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TLDR
The precipitin band which forms between the haemophilia antiserum and the serum containing Australia antigen stains faintly with sudan black, indicating that the antigen contains lipid.Abstract:
AUSTRALIA antigen was first identified using an antiserum produced in a transfused patient1,2. The antiserum gave a clear precipitin line in a double diffusion experiment when placed adjacent to the serum from an Australian aborigine. Pending further identification of the antigen, the geographic name “Australian antigen” was given to the reacting material found in the aborigine's serum. Specific antisera against this antigen can be produced by immunizing rabbits with serum containing Australia antigen, and subsequent absorption with serum which does not contain Australia antigen3. The precipitin band which forms between the haemophilia antiserum and the serum containing Australia antigen stains faintly with sudan black, indicating that the antigen contains lipid. It has a specific gravity of less than 1.21 and appears in the first peak in ‘Sephadex G-200’ column chromatography (indicating a high molecular weight)4.read more
Citations
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Journal ArticleDOI
DNA polymerase associated with human hepatitis B antigen.
P M Kaplan,P M Kaplan,P M Kaplan,Richard L. Greenman,Richard L. Greenman,Richard L. Greenman,John L. Gerin,John L. Gerin,John L. Gerin,Robert H. Purcell,Robert H. Purcell,Robert H. Purcell,William S. Robinson,William S. Robinson,William S. Robinson +14 more
TL;DR: DNA polymerase activity was detected in each of eight preparations of concentrated human hepatitis B antigen (HBAg) rich in Dane particles prepared by high-speed centrifugation of antigen-positive human plasma and in none of seven control preparations prepared in the same way from HBAg-negative plasma.
Journal ArticleDOI
A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.
TL;DR: Particles with properties similar to those associated with human hepatitis B were found in serum from woodchucks with chronic hepatitis and hepatocellular carcinoma and it is suggested that woodchuck hepatitis virus is a second member of a novel class of viruses represented by thehuman hepatitis B virus.
Journal ArticleDOI
Molecular biology of hepatitis B virus infection.
TL;DR: Antiviral therapies with nucleoside analog inhibitors of viral DNA synthesis delay sequelae, but cannot cure HBV infections due to the persistence of cccDNA in hepatocytes.
Journal ArticleDOI
A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.
TL;DR: A virus, with many of the unique characteristics of human hepatitis B virus, has been found in Beechey ground squirrels in northern California and is a member of the virus group that includes HBV and the virus recently found in woodchucks in the eastern United States and named woodchuck hepatitis virus.
Journal ArticleDOI
The heterogeneity of Australia antigen.
TL;DR: The relationship of these Australia (Au) particles to the infective agent itself is still unresolved, but present evidence suggests that they are fragments of viral lipoprotein envelope.
References
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Journal ArticleDOI
A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures
Robert G. Martin,Bruce N. Ames +1 more
TL;DR: Sucrose gradient centrifugation is found to be a suitable method for determining sedimentation coefficients of enzymes in protein mixtures and the sedimentation behavior of several of the enzymes in the pathway of histidine biosynthesis in S. typhimurium has been determined.
Book
Diseases of the Liver and Biliary System
Sheila Sherlock,James Dooley +1 more
TL;DR: Diseases of the liver and biliary system is studied to find out the main mechanisms leading to liver failure and its role in cirrhosis.
Journal ArticleDOI
A New Antigen in Leukemia Sera
TL;DR: Patients who receive large numbers of transfusions for anemia and other causes may develop precipitins in their blood, which were thought to be antibodies against serum lipoproteins which developed in the patients as a result of the repeated transfusions.
Journal ArticleDOI
A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.
TL;DR: This work has reported the presence of an isoantigen of human sera, rare or absent in normal U. S. and northern European populations but relatively common in patients with leukemia, and its role in the development of leukemia is unclear.