Journal ArticleDOI
Permeation of hairless mouse skin I: Experimental methods and comparison with human epidermal permeation by alkanols
TLDR
The permeation of intact hairless mouse skin by alkanols was studied, and data for the quasi-steady-state and nonstationary-state aspects of mass transfer are given and great similarity in all facets of behavior is noted.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1980-07-01. It has received 203 citations till now. The article focuses on the topics: Permeation.read more
Citations
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Journal ArticleDOI
Methods for in vitro percutaneous absorption studies. II. Animal models for human skin.
TL;DR: Percutaneous absorption of compounds through the skin of selected animal species was compared to that occurring with human skin, using in vitro diffusion cell techniques: pig skin and hairless mouse skin were the best animal models for the slower penetrating urea.
Journal ArticleDOI
Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure.
Jianhong Wu,Wei Liu,Chenbing Xue,Shun-Chang Zhou,Fengli Lan,Lei Bi,Huibi Xu,Xiangliang Yang,Fan-Dian Zeng +8 more
TL;DR: The results suggest that nanosize TiO(2) may pose a health risk to human after dermal exposure over a relative long time period, and that the pathological lesions are likely to be mediated through the oxidative stress induced by the deposited nanoparticles.
Journal ArticleDOI
Methods for in vitro percutaneous absorption studies IV: The flow‐through diffusion cell
TL;DR: Good agreement was obtained between the results of the in vivo and in vitro procedures on the permeation of cortisone and benzoic acid applied in a petrolatum vehicle and with rat skin in the flow-through and static-diffusion cells.
Journal ArticleDOI
Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity.
TL;DR: As there might be industry bias in many studies about the safety of topical ethanol applications, as well as a general lack of scientific research on the long-term effects, there is a requirement for independent studies on this topic.
Book
Dermatological And Transdermal Formulations
TL;DR: The structure and function of the skin common skin disorders and their topical treatment basic mathematical principles in skin permeation skin transport methods for studying percutaneous absorption formulation strategies for modulating skinpermeation formulation and development of dermatological dosage forms a case for multivariate optimization and product homogeneity transdermal drug delivery systems safety considerations.
References
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Mass transport Phenomena and Models: Theoretical Concepts
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Mechanism of percutaneous absorption. II. Transient diffusion and the relative importance of various routes of skin penetration.
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Mechanism of Percutaneous Adsorption: I. Routes of Penetration and the Influence of Solubility
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Mechanism of Percutaneous Absorption: III. The Effect of Temperature on the Transport of Non-Electrolytes Across the Skin*
TL;DR: A reconciliation of these contrary theories and a re-interpretation of the conflicting data is really long overdue and quite necessary if a useful link between studies of skin permeability in the laboratory and their relevance to the topical application of a drug by the physician is to be obtained.