Journal ArticleDOI
Pharmacodynamics of carbenicillin in hepatic and renal failure.
TLDR
The pharmacodynamics of carbenicillin were studied in 40 subjects after administration of a 2-g intravenous dose and the mean serum level at 1 hr was 103 ± 29 µg/ml in five s.Abstract:
The pharmacodynamics of carbenicillin were studied in 40 subjects after administration of a 2-g intravenous dose. The mean serum level of carbenicillin at 1 hr was 103 ± 29 µg/ml in five s...read more
Citations
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The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
TL;DR: The constancy of diazepam clearance indicates that drug plasma concentrations will not accumulate any more in the old than the young, and chronic dosage modifications based on pharmacokinetic considerations are unnecessary.
Journal ArticleDOI
Quantitative assessment of hepatic function by breath analysis after oral administration of (14C)aminopyrine.
TL;DR: The data suggest that the aminopyrine breath test is a safe, simple, qualitative and quantitative liver function test.
Journal ArticleDOI
Determinants of serum antipyrine half-lives in patients with liver disease
TL;DR: The most marked prolongation in antipyrine half-life was found in association with hypoalbuminaemia and hypoprothrombinaemia, suggesting that the cause for these changes was defective protein synthesis of microsomal enzyme protein.
Journal ArticleDOI
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
TL;DR: The data suggest that in vivo breath analysis after administration of 14C-amino-antipyrine (aminopyrine) was administered orally to healthy ambulant and nonambulant volunteers and to patients with portal cirrhosis, suggesting that hepatic drug metabolism might be conveniently assessed by a breath analysis technic.
Journal ArticleDOI
Piperacillin, a new penicillin active against many bacteria resistant to other penicillins.
TL;DR: The in vitro activity of piperacillin, a new semisynthetic piperazine penicillin derivative, was evaluated against 626 clinical isolates and compared with the activity of other beta-lactam antibiotics.
References
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Journal ArticleDOI
Artificial kidney function: kinetics of hemodialysis
Journal ArticleDOI
Renal failure in patients with cirrhosis of the liver: III. Evaluation of intrarenal blood flow by para-aminohippurate extraction and response to angiotensin
TL;DR: The decreased E PAH and associated renal functional changes noted in some patients with cirrhosis are explained best by a hemodynamic alteration involving renal cortical vasoconstriction with relative increase in medullary blood flow.
Journal ArticleDOI
New semi-synthetic penicillin active against Pseudomonas pyocyanea.
TL;DR: Most of the semi-synthetic penicillins developed from 6-amino-penicillanic acid have little or no activity against Pseudomonas pyocyanea.
Journal ArticleDOI
Persistence of antibiotics in blood of patients with acute renal failure. iii. penicillin, streptomycin, erythromycin and kanamycin
Calvin M. Kunin,Maxwell Finland +1 more
TL;DR: The results of studies on the persistence of four additional antibiotics; penicillin, streptomycin, erythromycin and kanamycin are presented following their administration to patients with severe renal failure to help delineate the optimum dosage regimens for these drugs in patients with markedly impaired renal function.