M
Malcolm Rowland
Researcher at University of Manchester
Publications - 296
Citations - 17796
Malcolm Rowland is an academic researcher from University of Manchester. The author has contributed to research in topics: Pharmacokinetics & Volume of distribution. The author has an hindex of 71, co-authored 294 publications receiving 16719 citations. Previous affiliations of Malcolm Rowland include University of California, San Francisco & University of Arizona.
Papers
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Journal ArticleDOI
Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.
Trudy Rodgers,Malcolm Rowland +1 more
TL;DR: Improvement in parameter prediction was largely due to the incorporation of distribution processes related to drug ionisation, an issue that is not addressed in earlier equations.
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Clearance concepts in pharmacokinetics
TL;DR: The kinetics of a drug eliminated by first-order processes in a perfusion-limited isolated perfused organ system are examined and the virtue of using clearance, instead of half-life, as a correlative parameter between these systems is stressed.
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Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate‐to‐strong bases
TL;DR: Overall improvement in prediction should facilitate the further application of WBPBPK modeling, where time, cost and labor requirements associated with experimentally determining Kpu's have, to a large extent, deterred its application.
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Physiologically-based pharmacokinetics in drug development and regulatory science.
TL;DR: Specific advances and contemporary challenges with respect to predicting the processes of drug clearance, distribution, and absorption are reviewed, together with the ability to anticipate the quantitative extent of PK-based drug-drug interactions and the impact of age, genetics, disease, and formulation.
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Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans.
Pate D. Thomson,Kenneth L. Melmon,James A. Richardson,Keith Cohn,Walter Steinbrunn,Robert Cudihee,Malcolm Rowland +6 more
TL;DR: The pharmacokinetics of intravenously administered lidocaine were studied in 10 normal subjects, 11 patients with heart failure, 8 patients with alcoholic liver disease, and 6 chronic rena...