Journal ArticleDOI
Photocatalytic Late-Stage C-H Functionalization.
TLDR
A review of photocatalytic late-stage C-H functionalization strategies for small molecule drugs, agrochemicals, and natural products can be found in this article .Abstract:
The emergence of modern photocatalysis, characterized by mildness and selectivity, has significantly spurred innovative late-stage C-H functionalization approaches that make use of low energy photons as a controllable energy source. Compared to traditional late-stage functionalization strategies, photocatalysis paves the way toward complementary and/or previously unattainable regio- and chemoselectivities. Merging the compelling benefits of photocatalysis with the late-stage functionalization workflow offers a potentially unmatched arsenal to tackle drug development campaigns and beyond. This Review highlights the photocatalytic late-stage C-H functionalization strategies of small-molecule drugs, agrochemicals, and natural products, classified according to the targeted C-H bond and the newly formed one. Emphasis is devoted to identifying, describing, and comparing the main mechanistic scenarios. The Review draws a critical comparison between established ionic chemistry and photocatalyzed radical-based manifolds. The Review aims to establish the current state-of-the-art and illustrate the key unsolved challenges to be addressed in the future. The authors aim to introduce the general readership to the main approaches toward photocatalytic late-stage C-H functionalization, and specialist practitioners to the critical evaluation of the current methodologies, potential for improvement, and future uncharted directions.read more
Citations
More filters
Journal ArticleDOI
Recent advances in electrochemical generation of 1,3-dicarbonyl radicals from C–H bonds
TL;DR: In this paper , 1,3-Dicarbonyl derivatives are used as reagents for cross-coupling reactions in the context of electron-based electron reagents.
Journal ArticleDOI
Late-Stage C-H Functionalization of Azines.
Hillary Nguyen,Andrew McNally +1 more
TL;DR: There is a growing interest in late-stage functionalization (LSF) reactions that focus on advanced candidate compounds that are often complex structures with multiple heterocycles, functional groups, and reactive sites as mentioned in this paper.
Journal ArticleDOI
Synthesis of Unsymmetrical Diaryl Oxindoles/Isoquinolinediones Using 2-Phenoxy-1H-benzo[d]imidazole as Integrated Diarylating Reagent
TL;DR: In this paper , a novel synthesis of unsymmetrical 3,3-diaryl oxindoles and 4,4-diagraml isoquinolinediones through the cascade reactions of 2-phenoxy-1H-benzo[d]imidazoles with diazo oxindole or díazo homophthalimides was presented.
Journal ArticleDOI
Shining a Light on the Advances, Challenges and Realisation of Utilising Photoredox Catalysis in Pharmaceutical Development
Alan Steven,Rachel J. Kahan +1 more
TL;DR: In this paper , the authors provide insight on the successes and difficulties encountered when applying photoredox catalysis to pharmaceutical development, and it is hoped greater understanding of the challenges faced by the pharmaceutical industry will inform future research and encourage collaboration.
Journal ArticleDOI
The mechanism of visible light-induced C-C cross-coupling by Csp3-H bond activation.
TL;DR: In this paper , the authors summarize representative experimental and computational mechanistic studies, highlighting weaknesses, strengths, and synergies between the two approaches, and provide the knowledge allowing faster and rational advances in the field.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
TL;DR: The conversion of these bench stable, benign catalysts to redox-active species upon irradiation with simple household lightbulbs represents a remarkably chemoselective trigger to induce unique and valuable catalytic processes.
Journal ArticleDOI
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI
Organic Photoredox Catalysis
TL;DR: An overview of the basic photophysics and electron transfer theory is presented in order to provide a comprehensive guide for employing this class of catalysts in photoredox manifolds.
Related Papers (5)
Shining photocatalysis by gold-based nanomaterials
Selective C-H Functionalization of Electron-Deficient Aromatics by Carbamoylsilanes: Synthesis of Aromatic Carbinolamines or Amides.
Yanhong Liu,Pei Cao,Jianxin Chen +2 more