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Physiology in health and disease

Carl J. Wiggers
- 01 Mar 1935 - 
- Vol. 189, Iss: 2, pp 276
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This article is published in The American Journal of the Medical Sciences.The article was published on 1935-03-01. It has received 337 citations till now. The article focuses on the topics: Disease.

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Localized disorders in myocardial contraction. Asynergy and its role in congestive heart failure.

TL;DR: The pattern of left ventricular contraction is described as a "series of sequential fractionate contractions of muscle bundles" and the possibility that unco-ordinated contraction of the heart results from a combination of normal and abnormal muscle has received little attention.
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Ventricular interdependence: Significant left ventricular contributions to right ventricular systolic function

TL;DR: Although always present, ventricular interdependence is most apparent with sudden postural and respiratory changes in ventricular volume, and is probably best explained by the balance of forces at the interventricular sulcus, the material properties, and cardiac dimensions.
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Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in Man

TL;DR: The IHR may prove valuable as an index of myocardial function in man, since it can be measured simply and safely in clinical practice and was significantly related to each available index of left ventricular function after blockade.
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Vasodilator Therapy for Heart Failure The Influence of Impedance on Left Ventricular Performance

TL;DR: The role of the arterial system in determining the performance of the diseased left ventricle has been relatively neglected in traditional thinking about heart failure, but recent studies have demonstrated dramatic hemodynamic improvement duringistration of vasodilator drugs in patients with left ventricular failure.
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Range of normal blood pressure: a statistical and clinical study of 11,383 persons

TL;DR: The determination of blood pressure is the third most important routine physiologic measurement that the modern physician uses with a fine degree of precision, and for long range evaluation of the health of the average person it is far more significant than the temperature and the pulse.