Journal ArticleDOI
Potentiation of Betel-Induced Alterations of Mouse Glandular Stomach Mucosa by Tobacco in Studies Simulating Betel Addiction
Soumitra Sen,Geeta Talukder,Archana Sharma +2 more
- Vol. 25, Iss: 4, pp 209-215
TLDR
The results may exemplify the way in which the various chewing mixtures, which are ingested daily in relatively large quantities, could affect carcinogenesis in habitual chewers.Abstract:
Histopathological effects of chewing of betel quid with tobacco was studied by simulating four different chewing habits, using mouse glandular stomach mucosa as a model system. Chronic oral administration for five months resulted in marked intestinal metaplasia in all animals receiving extract of tobacco with betel nut and lime and extract of tobacco with betel leaf, nut and lime, in doses normally ingested by human addicts. Tobacco markedly augmented the effect of other ingredients. Lime and Piper betle L. var. bangla probably played a protectant role by reducing the dysplasia and metaplasia. In the light of the growing use of smokeless tobacco and betel chewing habits, our results may exemplify the way in which the various chewing mixtures, which are ingested daily in relatively large quantities, could affect carcinogenesis in habitual chewers.read more
Citations
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Book ChapterDOI
Widespread tannin intake via stimulants and masticatories, especially guarana, kola nut, betel vine, and accessories.
TL;DR: Research and popular education on the deleterious effects of excessive tannin intake could do much to reduce the heavy burden of early mortality and health care, especially in developing countries.
Journal ArticleDOI
Plant extracts as modulators of genotoxic effects
TL;DR: Higher plants used extensively in traditional medicines are increasingly being screened for their role in modulating the activity of environmental genotoxicants, and plant extracts able to modify the process of mutagenesis, which involves alteration in the genetic material are extended.
Book ChapterDOI
Potential Genotoxic and Cytotoxic Effects of Plant Extracts
TL;DR: The medicinal use of plants is probably as old as human kind itself and many of the plants species used for this purpose have been found to contain therapeutic substances which can be extracted and used in preparation of drugs.
Journal ArticleDOI
Betel quid chewing as an environmental risk factor for breast cancer.
Mishi Kaushal,Ashwani Kumar Mishra,B.S. Raju,Rakhshan Ihsan,Anurupa Chakraborty,Jaganath Sharma,Eric Zomawia,Yogesh Verma,Amal C Kataki,Sujala Kapur,Sunita Saxena +10 more
TL;DR: This study suggests betel quid chewing as a significant risk factor for developing breast cancer and the lack of detoxification enzymes GSTT1 and GSTM1 are associated with reduced breast cancer risk.
Journal ArticleDOI
Inhibition of clastogenic effects of nicotine by chlorophyllin in mice bone marrow cells in vivo
TL;DR: The use of green plant parts in modifying the genotoxicity of different agents may be related to the protective action of chlorophyllin, which was tested in vivo on mice bone marrow cells.
References
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Journal ArticleDOI
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
Journal ArticleDOI
Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment
D. J. Jussawalla,V. A. Deshpande +1 more
TL;DR: It is revealing to find that the high risk sites involved in tobacco chewers appear to be the least affected in smokers, and vice versa.
Journal ArticleDOI
Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients
TL;DR: The mutagenic activity of betel quid and its ingredients was determined using Salmonella typhimurium tester strains TA 100, TA 1535, TA 98, and TA 1538, both in the presence and absence of S9 mixture.
Journal ArticleDOI
Mutagenicity of betel quid and its ingredients using mammalian test systems.
TL;DR: The mutagenic potential of betel quid and its ingredients (known colloquially as PAN) were tested in two short term mutagenicity assays, the micronucleus test and a mammalian gene mutation test and the data presented correlate well with previous tumorigenicity data on these compounds.
Journal ArticleDOI
A study of betel quid carcinogenesis. IV. Analysis of the saliva of betel chewers: a preliminary report.
TL;DR: This article found N-nitrosoguvacoline in the saliva of betel-quid chewers (2.2-350 ppb) when the quid contains tobacco, N′-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.0-2.3 ppb), and N′-(nitrosoanatabine) (3.2−39.5 ppb).