Patent
Prolonged release microcapsules
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In this paper, a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptic and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, wherein the composition ratio of lactic acid/glycolic acid in the copolymers orAbstract:
This invention provides a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of said polypeptide and an oil layer containing a copolymer or homopolymer having a weight-average molecular weight of 7,000 to 30,000, wherein the composition ratio of lactic acid/glycolic acid in the copolymer or homopolymer is 80/10 to 100/0, and then subjecting said water-in oil emulsion to microencapsulation.read more
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References
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Polylactide-drug mixtures
TL;DR: In this article, it was claimed that the drug is biodegradable in the body into normal or essentially normal METABOLIC products that have no deletterIous or UNTOWARD EFFECT on the body.
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Continuous release pharmaceutical compositions
TL;DR: In this paper, a polylactide and a pharmacologically active acid stable polypeptide are combined in an essentially monophasic manner, with a minimal, or no induction period prior to the release.
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Drug delivery system and method of making the same
Tice Thomas R,Richard M. Gilley +1 more
TL;DR: A compatible, biodegradable microcapsule delivery system for active ingredients, including hormonally active peptides, proteins, or other bioactive molecules, and a method of making the same was proposed in this article.
Patent
Prolonged release microcapsule and its production
TL;DR: A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner annealing layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water soluble drug.
Journal ArticleDOI
Controlled Release of a Luteinizing Hormone-Releasing Hormone Analogue from Poly(d,l-lactide—co-glycolide) Microspheres
TL;DR: The performance in vivo of nafarelin acetate, a potent analogue of luteinizing hormone-releasing hormone, microencapsulated in poly(d,l-lactide-co-glycolide), was evaluated and compound release was shown to be effected by polymer erosion rather than by diffusion.