Figure 4. Vaccination ameliorates antinociceptive effect of oxycodone. Mean (±SEM) tail-withdrawal latency in Oxy-TT (N=12) vaccinated rats as compared to TT (N=11-12) control rats prior to and post-IVSA training in A) Cohort 1 and B) Cohort 2. C) In Cohort 1, a non-contingent injection heroin (1 mg/kg, s.c.) showed no difference between groups, but persistence of the difference after oxycodone injection (2 mg/kg, s.c.). Post hoc tests: Significant differences between the groups is indicated with #. Significant differences within group compared with Pre are indicated by * and compared with the most prior observation before a drug injection (60 or 120 min) with &.
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