C
Candy S. Hwang
Researcher at Scripps Research Institute
Publications - 26
Citations - 495
Candy S. Hwang is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Fentanyl & Oxycodone. The author has an hindex of 11, co-authored 25 publications receiving 366 citations. Previous affiliations of Candy S. Hwang include University of Southern California & Southern Connecticut State University.
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Journal ArticleDOI
Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats
E. Andrew Townsend,Steven Blake,Kaycee E. Faunce,Candy S. Hwang,Candy S. Hwang,Yoshihiro Natori,Yoshihiro Natori,Bin Zhou,Paul T. Bremer,Kim D. Janda,Matthew L. Banks +10 more
TL;DR: The effectiveness of a fentanyl-tetanus toxoid conjugate vaccine to alter fentanyl self-administration and the expression of withdrawal-associated increases in fentanyl-vs-food choice are determined to support the potential and further consideration of immunopharmacotherapies as candidate treatments to address the current opioid crisis.
Journal ArticleDOI
Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality
Candy S. Hwang,Paul T. Bremer,Cody J. Wenthur,Sam On Ho,SuMing Chiang,Beverly A. Ellis,Bin Zhou,Gary Fujii,Kim D. Janda +8 more
TL;DR: Investigation of month-long stability of the two lead formulations revealed that the TLR9 but not theTLR3 formulation was stable when stored as a lyophilized solid or as a liquid over 30 days, suggesting that this vaccine formulation is suitable for mitigating the harmful effects of heroin, even following month- long storage at room temperature.
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Efficacious Vaccine against Heroin Contaminated with Fentanyl.
TL;DR: A vaccine containing a mixture of heroin and fentanyl hapten-conjugates as a proof-of-concept immunotherapy targeting a combination of these drugs showed drug retention in serum and reduced distribution in the brain after administration of an intravenous bolus of heroin coadministered with fentanyl.
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Prophylactic vaccination protects against the development of oxycodone self-administration.
TL;DR: Protection against the reinforcing effects of an anti‐oxycodone vaccine in rats is demonstrated and may entirely prevent repeated use in some individuals who otherwise would become addicted.
Journal ArticleDOI
Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.
Jacques D. Nguyen,Yanabel Grant,Yanabel Grant,Kevin M. Creehan,Kevin M. Creehan,Candy S. Hwang,Sophia A. Vandewater,Kim D. Janda,Maury Cole,Michael A. Taffe,Michael A. Taffe +10 more
TL;DR: Additive effects of THC and oxycodone are demonstrated and the potential use of THC to enhance therapeutic efficacy, and to reduce the abuse, of opioids is suggested.