Journal ArticleDOI
Regioselective Synthesis of Thieno[3,2- c ][1]benzopyran-4-ones by Thio- Claisen Rearrangement
Krishna C. Majumdar,A. Biswas +1 more
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TLDR
In this paper, thermal thio-Claisen rearrangement of 4-allylthio[1]benzopyran-2-ones in refluxing quinoline for 0.5-8.0 h was performed.Abstract:
A number of thieno[3,2-c][1]benzopyran-4-ones, potential antiinflamatory, antipyretic, and antiallergic drugs, are synthesized in 65–80% yield by thermal thio-Claisen rearrangement of 4-allylthio[1]benzopyran-2-ones in refluxing quinoline for 0.5–8.0 h. The 4-allylthio[1]benzopyran-2-ones are in turn prepared in 75–85% yield from 4-mercaptocoumarin and different allylic halides by phase-transfer-catalysed alkylation with TBAB or BTEAC catalyst in chloroform-aq. NaOH at room temperature.read more
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Catalyst-free, step and pot economic, efficient mercaptoacetylative cyclisation in H2O: synthesis of 3-mercaptocoumarins
TL;DR: In this article, a tandem Knoevenagel condensation and mercaptoacetylative cyclisation procedure was proposed for the synthesis of 3-mercaptocoumarins in water.
Patent
Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use
Steven Do,Goldsmith Richard,Tim Heffron,Aleksandr Kolesnikov,Steven T. Staben,Olivero Alan G,Michael Siu,Daniel P. Sutherlin,Bing-Yan Zhu,Paul Goldsmith,Tracy Bayliss,Adrian Folkes,Pegg Neil +12 more
TL;DR: In this article, benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K.
Journal ArticleDOI
Regiospecific synthesis, antibacterial and anticoagulant activities of novel isoxazoline chromene derivatives
Imen Zghab,Belsem Trimeche,Mohamed Ben Mansour,Mohsen Hassine,David Touboul,Hichem Ben Jannet +5 more
TL;DR: In this article, the synthesis and pharmacological evaluation of new series of 4-((3-aryl-4,5-dihydroisoxazol-5-yl)methoxy)-2H-chromen-2-ones 3a-f prepared by cycloaddition reaction using various arylnitrile oxides with the suitable 4-(allyloxy)2H-(chromen)-2-one 2a 2a is described.
Patent
Benzoxazepin PI3K inhibitor compounds and methods of use
Nicole Blaquiere,Steven Do,Danette Dudley,Adrian J. Folkes,Robert Heald,Timothy P. Heffron,Mark Jones,Aleksandr Kolesnikov,Chudi Ndubaku,Alan G. Olivero,Stephen Price,Steven T. Staben,Lan Wang +12 more
TL;DR: In this paper, the benzoxazepin compounds of Formula (I) including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof are defined.
Journal ArticleDOI
Synthesis and evaluation of chromene-based compounds containing pyrazole moiety as antimicrobial agents
TL;DR: 20 hybrid compounds synthesized with an intention to synergize the antimicrobial activity of 1,3-diphenyl pyrazole and chromene derivatives show reasonable antibacterial and antifungal activity.
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Phase transfer catalysis
TL;DR: Ion Pairs and ion pair extraction as mentioned in this paper, the nature of phase transfer catalysis ion pairs in organic media Extraction of Ion Pairs from Aqueous Solution Crown Ethers, Cryptates, and Other Chelating Agents as Extractants Solid-Liquid Anion Exchange Mechanism of Phase Transfer Catalysis Mechanistic Investigations Empirical Catalyst Evaluations Unusual and Polymer Supported Catalysts Practical Applications of PTC Applications General Experimental Procedures Formation of Halides Preparation of Nitriles Ester Formation Miscellaneous Displacements Thiols and Sulfides Prepar