D
Danielle Gully
Researcher at Centre national de la recherche scientifique
Publications - 98
Citations - 3265
Danielle Gully is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Neurotensin & Neurotensin receptor. The author has an hindex of 27, co-authored 98 publications receiving 3210 citations. Previous affiliations of Danielle Gully include University of Notre Dame.
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Journal ArticleDOI
Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor
Danielle Gully,M Canton,Robert Boigegrain,F. Jeanjean,J C Molimard,M. Poncelet,C Gueudet,Michel Heaulme,R Leyris,Aline Brouard +9 more
TL;DR: Being a potent and selective neurotensin receptor antagonist, SR 48692 may be considered as a powerful tool for investigating the role of neurotens in physiological and pathological processes.
Journal ArticleDOI
The 100-kDa Neurotensin Receptor Is gp95/Sortilin, A Non-G-Protein-coupled Receptor
Jean Mazella,Nicole Zsürger,Valérie Navarro,Joëlle Chabry,Mourad Kaghad,Daniel Caput,Pascual Ferrara,Natalio Vita,Danielle Gully,J P Maffrand,Jean-Pierre Vincent +10 more
TL;DR: Affinity labeling and binding experiments showed that the 110-kDa NT3 receptor can be partly transformed into a higher affinity by cotransfection with furin, which is the first transmembrane neuropeptide receptor that does not belong to the superfamily of G-protein-coupled receptors.
Journal ArticleDOI
Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor
Natalio Vita,Patrick Laurent,S. Lefort,Pascale Chalon,Xavier Dumont,Mourad Kaghad,Danielle Gully,G Le Fur,P. Ferrara,Daniel Caput +9 more
TL;DR: A human neurotensin receptor (hNTR) cDNA was cloned from the colonic adenocarcinoma cell line HT29 results in the expression of receptors with pharmacological properties similar to those found with HT29 cells.
Journal ArticleDOI
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-((1S)-2-cyclopropyl- 1-(3-fluoro-4-methylphenyl)ethyl)5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor 1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
Guy Griebel,Jacques Simiand,Régis Steinberg,M. Jung,Danielle Gully,Pierre Roger,Michel Geslin,Bernard Scatton,Jean-Pierre Maffrand,Philippe Soubrie +9 more
TL;DR: Results indicate that SSR125543A shows good activity in acute and chronic tests of unavoidable stress exposure, suggesting that it may have a potential in the treatment of depression and some forms of anxiety disorders.
Journal Article
Biochemical and Pharmacological Activities of SR 142948A, a New Potent Neurotensin Receptor Antagonist
Danielle Gully,Bernard Labeeuw,Robert Boigegrain,F. Oury-Donat,Andre Bachy,Martine Poncelet,Régis Steinberg,Marie-Françoise Suaud-Chagny,Vincent Santucci,Natalio Vita,Florence Pecceu,Catherine Labbé-Jullié,Patrick Kitabgi,Philippe Soubrie,G Le Fur,J P Maffrand +15 more
TL;DR: A new and extremely potent neurotensin (NT) receptor antagonist that retains the properties of the lead compound SR 48692, reveals a wider spectrum of activity thanSR 48692 and represents an additional tool for further exploration of the therapeutic potential of this class of compounds.