Journal ArticleDOI
Role of the Rostral Ventrolateral Medulla in Maintenance of Blood Pressure in Rats With Goldblatt Hypertension
TLDR
The aim of the present study was to examine the participation of the rostral ventrolateral medulla (RVLM) in the maintenance of hypertension in rats submitted to the renovascular Goldblatt (two-kidney, one clip) procedure and inhibited or stimulated this area with the use of drugs such as glycine, L-glutamate, or kynurenic acid.Abstract:
The aim of the present study was to examine the participation of the rostral ventrolateral medulla (RVLM) in the maintenance of hypertension in rats submitted to the renovascular Goldblatt (two-kidney, one clip) procedure. We inhibited or stimulated this area with the use of drugs such as glycine, l-glutamate, or kynurenic acid. (1) Bilateral microinjection of glycine (100 nmol, 200 nL, n=13) into the RVLM of hypertensive rats produced a decrease in mean arterial blood pressure (MAP) from 177.2±29.3 to 102.3±20.9 mm Hg ( P P P Pread more
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Journal ArticleDOI
Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone.
Roger A. L. Dampney,J. Horiuchi,T. Tagawa,Marco Antônio Peliky Fontes,P.D Potts,Jaimie W. Polson +5 more
TL;DR: The current evidence indicates that the resting activity of RVLM presympathetic neurons is determined by the balance of powerful tonic excitatory and inhibitory synaptic inputs.
Journal ArticleDOI
Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions
Roger A. L. Dampney,Jouji Horiuchi,Suzanne Killinger,M. J. Sheriff,Peter S. P. Tan,Lachlan M. McDowall +5 more
TL;DR: In the present brief review, the mechanisms within the brain that can influence RSNA are considered, focusing particularly on hypothalamic mechanisms.
Journal ArticleDOI
Role of the Medulla Oblongata in Hypertension
Eduardo Colombari,Monica Akemi Sato,Sergio Luis Cravo,Cássia T. Bergamaschi,Ruy R. Campos,Oswaldo Ubriaco Lopes +5 more
TL;DR: This work focuses on the medulla oblongata, the primary site of cardiorespiratory reflex integration in nucleus tractus solitarius, which is critical to the tonic and reflexive regulation of AP.
Neural, Hormonal and Renal Interactions in Long-Term Blood Pressure Control LONG-TERM REGULATION OF ARTERIAL BLOOD PRESSURE BY HYPOTHALAMIC NUCLEI: SOME CRITICAL QUESTIONS
TL;DR: A brief review of the mechanisms within the brain that can influence renal sympathetic nerve activity (RSNA), focusing particularly on hypothalamic mechanisms, is given in this article, where a number of neurotransmitters and neuromodulators are involved in these tonic excitatory and inhibitory effects, including glutamate, GABA, angiotensin II and nitric oxide.
Journal ArticleDOI
Excitatory Amino Acids in the Rostral Ventrolateral Medulla Support Blood Pressure in Spontaneously Hypertensive Rats
TL;DR: The results suggest that the balance of excitatory and inhibitory influences on RVLM vasomotor neurons driven by tonically active EAA-mediated inputs to the RVLM is disrupted in SHR and may contribute to the hypertension inSHR.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions
P. G. Guertzenstein,Ann Silver +1 more
TL;DR: In cats anaesthetized with pentobarbitone sodium, atropinized by i.v. atropine methyl nitrate and artificially ventilated, experiments were carried out to localize the site where glycine acts on the ventral surface of the medulla when, on topical application through paired Perspex rings caudal to the trapezoid bodies, it produces a fall in arterial blood pressure.
Journal ArticleDOI
Neurones within the "chemosensitive area" on the ventral surface of the brainstem which project to the intermediolateral column.
TL;DR: It is demonstrated that neurones within the “chemosensitive area” of the brainstem project to the thoracic intermediolateral column, and the function of these neurones is discussed in regard to the regulation of blood pressure.
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Excitatory Amino Acids in the Rostral Ventrolateral Medulla Support Blood Pressure in Spontaneously Hypertensive Rats
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T. Tagawa,Roger A. L. Dampney +1 more