Journal ArticleDOI
Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment
TLDR
It is concluded that self-administration behavior of rats reinforced on a progressive ratio schedule can provide useful information about changes in the reinforcing efficacy of specific drugs.Abstract:
Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ratio completed each day was found to be relatively stable, sensitive to changes in dose, and drastically reduced by pretreatment with haloperidol (0.05 mg/kg). We conclude that self-administration behavior of rats reinforced on a progressive ratio schedule can provide useful information about changes in the reinforcing efficacy of specific drugs.read more
Citations
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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
TL;DR: It is suggested that dopamine may be more important to incentive salience attributions to the neural representations of reward-related stimuli and is a distinct component of motivation and reward.
Journal ArticleDOI
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
TL;DR: This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats to examine psychostimulant and opiate reinforcement.
Journal ArticleDOI
Conditioned place preference: What does it add to our preclinical understanding of drug reward?
Michael T. Bardo,Rick A. Bevins +1 more
TL;DR: A theoretical overview of some critical issues relevant to conditioned place preference is provided and it seems clear that CPP measures a learning process that is fundamentally distinct from drug self-administration.
Journal ArticleDOI
The role of dopamine in drug abuse viewed from the perspective of its role in motivation
TL;DR: Dopamine is involved in the induction and in the expression of behavioural sensitization by repeated exposure to various drugs of abuse, and might be instrumental for the acquisition of responding to drug-related incentive stimuli (incentive learning).
Journal ArticleDOI
Animal models of drug craving
TL;DR: The development of animal models of drug craving will have heuristic value and allow a systematic investigation of the neurobiological mechanisms of craving, and these animal models are evaluated according to reliability and predictive validity.
References
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Journal ArticleDOI
Progressive Ratio as a Measure of Reward Strength
TL;DR: Four rats were trained to press a lever on a ratio schedule of reinforcement in which the number of lever presses required on each consecutive run increased by a fixed increment.
Journal ArticleDOI
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens.
TL;DR: The hypothesis that non-striatal dopamine may subserve cocaine reward is supported, as several 6-OHDA treated animals displayed a pattern of behaviour resembling extinction, where a high rate of lever pressing was followed by cessation of responding.
Journal ArticleDOI
On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine.
TL;DR: The role of ascending noradrenergic and dopaminergic systems in intravenous self-administration of cocaine in rats was investigated by examining the effects of 6-hydroxydopamine-induced lesions of these systems on responding for the drug on a FR-1 schedule of reinforcement.
Journal ArticleDOI
Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.
H De Wit,Roy A. Wise +1 more
Journal ArticleDOI
The estrous cycle affects cocaine self-administration on a progressive ratio schedule in rats
TL;DR: It appears that the estrous cycle influences an animal's motivation to self-administer cocaine, and female rats reached higher breaking points during estrus than during other stages of the estrus.