Journal ArticleDOI
Shared lipid phosphate carrier in the biosynthesis of teichoic acid and peptidoglycan.
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TLDR
Poly-isoprenols have been demonstrated to participate in the synthesis of O-antigen1, peptidoglycan2, 3 and mannan4, and all these membrane lipids so far isolated and identified have been shown to be the C55 polyisopreol, undecaprenol, although it has not yet been demonstrated that they are the same isomer.Citations
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Journal ArticleDOI
A Continuum of Anionic Charge: Structures and Functions of d-Alanyl-Teichoic Acids in Gram-Positive Bacteria
TL;DR: The structures and functions of d- alanyl-TAs, the d-alanylation system encoded by the dlt operon, and the roles of TAs in cell growth are addressed.
Journal ArticleDOI
The biosynthesis of peptidoglycan lipid‐linked intermediates
TL;DR: This review summarizes the current knowledge on the membrane steps leading to the formation of the lipid II intermediate, i.e. the substrate of the polymerization reactions.
Journal ArticleDOI
Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus.
Jennifer Campbell,Anil Kumar Singh,Anil Kumar Singh,John P. Santa Maria,Younghoon Kim,Stephanie Brown,Jonathan G. Swoboda,Eleftherios Mylonakis,Brian J. Wilkinson,Suzanne Walker +9 more
TL;DR: It is shown that blocking the expression of wall teichoic acids (WTAs) by inhibiting the first enzyme in the pathway, TarO, sensitizes methicillin-resistant S. aureus (MRSA) strains to β-lactams even though the β- lactam-resistant transpeptidase, PBP2A, is still expressed.
Book ChapterDOI
Cell Wall Structure, Synthesis, and Turnover
TL;DR: It is now clear that both types of polymer are essential for normal wall function and morphogenesis.
References
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Journal ArticleDOI
Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.
TL;DR: Bacitraciin is a polypeptide antibiotic produced by certain strainis of Bacillus licheniformis that inhibits bacterial cell wall synthesis and induces the accumulation in Staphylococcus aureus of UDP-acetylmuramyl-pentapeptide,I a precursor of the cell wall.
Journal ArticleDOI
Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol.
TL;DR: The purpose of the present paper is to report that lipid-P- P-disaccharide-pentapeptide has been obtained in a highly purified form from Mlicrococcus lysodeikticus, and that the nature of the lipid moiety of this intermediate has beeln elucidated.
Journal ArticleDOI
Characterization of a polyisoprenoid compound functional in O-antigen biosynthesis.
Journal ArticleDOI
Biosynthesis of the Peptidoglycan of Bacterial Cell Walls II. PHOSPHOLIPID CARRIERS IN THE REACTION SEQUENCE
TL;DR: Ristocetin and vancomycin at low concentrations inhibited utilization of GlcNAc-MurNAc(-pentapeptide)-P-P-phospholipid for peptidoglycan synthesis, thus confirming that this reaction is the step in peptidglycan synthesis which is most sensitive to these antibiotics.
Journal ArticleDOI
The biosynthesis of mannosyl-1-phosphoryl-polyisoprenol in Micrococcus lysodeikticus and its role in mannan synthesis.
TL;DR: All the available evidence indicates that the structure of this compound is mannosyl-l-phosphoryl, which is likely to be a-D-mannosyl-(1 - 3')-diglyceride.