Singleton Partial Molar Pregnancy Delivered in Third Trimester: A Case Report

TLDR: The optimal management of hydatidiform mole with coexistent live fetus is currently uncertain and Clinicians are recommended to present their individual cases for the establishment of guidelines for the management and prenatal counseling for pregnancies with partial mole withCoexistent fetuses.

Abstract: Background: A partial mole is the result of fertilization of a haploid ovum by two sperms or duplication of one sperm, resulting in a triploid karyotype (69 XXY, 69 XXX, 69 XYY). To date, there are very few cases of histo-pathologically confirmed partial moles with diploid karyotypes which survived. This case is reported to highlight the rarest variant of partial molar pregnancy. Case presentation: Here we present a case of singleton partial molar pregnancy co-existing with a live fetus delivered to an 18 years old primigravida lady at Jimma university medical center (JUMC) after amenorrhea of 8 months. She presented with eclamptic seizure for which she was admitted with a diagnosis of Eclampsia in 3rd trimester pregnancy. Malpresentation (breech) with? Abruptio placenta to rule out partial mole was considered initially. Cesarean section (C/S) was done to effect delivery of an alive female neonate weighing 1100 gm with an APGAR score of 4, 6 & 7 at 1st, 5th & the 10th minute of life. The neonate is admitted to neonatal intensive care unit (NICU) where she is complicated by early neonatal death after 65 hours of stay despite many efforts, the possible cause of death being respiratory failure secondary to underlying prematurity. Grossly placenta was single, weighing 1200 gm and invaded by vesicles except its membrane. Histo-pathological finding of placenta was consistent with partial mole. Conclusion: The optimal management of hydatidiform mole with coexistent live fetus is currently uncertain. Clinicians are recommended to present their individual cases for the establishment of guidelines for the management and prenatal counseling for pregnancies with partial mole with coexistent fetuses.