Sound asleep: Processing and retention of slow oscillation phase-targeted stimuli
TLDR
It is speculated that while simpler forms of learning may occur during sleep, neocortically based memories are not readily established during deep sleep, and neural stimulus processing depends importantly on the slow oscillation phase.Abstract:
The sleeping brain retains some residual information processing capacity. Although direct evidence is scarce, a substantial literature suggests the phase of slow oscillations during deep sleep to be an important determinant for stimulus processing. Here, we introduce an algorithm for predicting slow oscillations in real-time. Using this approach to present stimuli directed at both oscillatory up and down states, we show neural stimulus processing depends importantly on the slow oscillation phase. During ensuing wakefulness, however, we did not observe differential brain or behavioral responses to these stimulus categories, suggesting no enduring memories were formed. We speculate that while simpler forms of learning may occur during sleep, neocortically based memories are not readily established during deep sleep.read more
Citations
More filters
Journal Article
upgrading the sleeping brain with targeted memory reactivation : 142
TL;DR: Investigations of these subtle manipulations of memory processing during sleep can help elucidate the mechanisms of memory preservation in the human brain.
Journal ArticleDOI
Cortical circuit activity underlying sleep slow oscillations and spindles.
TL;DR: When spindles are nested in slow oscillation upstates, maximum Pyr activity appears to concur with strong perisomatic inhibition of Pyr cells via PV-Ins and low dendritic inhibition via SOM-Ins (i.e., conditions that might optimize synaptic plasticity within local cortical circuits).
Journal ArticleDOI
Driving Sleep Slow Oscillations by Auditory Closed-Loop Stimulation—A Self-Limiting Process
TL;DR: Testing the limits of driving SOs through closed-loop auditory stimulation in healthy humans revealed a rapidly fading phase-locked spindle activity during repetitive click stimulation, suggesting that spindle refractoriness contributes to this protective mechanism.
Journal ArticleDOI
Slow-wave sleep: From the cell to the clinic.
Damien Leger,Eden Debellemaniere,Arnaud Rabat,Virginie Bayon,Karim Benchenane,Mounir Chennaoui +5 more
TL;DR: This review aims to gather the current knowledge extending from the cell to the clinic, in order to construct an overview of what is currently known about so-called SWS, and describes its role in physiology and cognition to assess its association with clinical aspects.
Journal ArticleDOI
The Fall of Sleep K-Complex in Alzheimer Disease.
Luigi De Gennaro,Maurizio Gorgoni,Flaminia Reda,Giulia Lauri,I. Truglia,Susanna Cordone,Serena Scarpelli,Anastasia Mangiaruga,Aurora D'Atri,Giordano Lacidogna,Michele Ferrara,Camillo Marra,Paolo Maria Rossini +12 more
TL;DR: Although no significant changes of ≤1 Hz SWA are detectable over frontal areas in AD, KC density decreases over the same location, and its decrease is related to the cognitive decline.
References
More filters
Journal ArticleDOI
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
TL;DR: Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.
Journal ArticleDOI
Nonparametric statistical testing of EEG- and MEG-data
Eric Maris,Robert Oostenveld +1 more
TL;DR: This paper forms a null hypothesis and shows that the nonparametric test controls the false alarm rate under this null hypothesis, enabling neuroscientists to construct their own statistical test, maximizing the sensitivity to the expected effect.