Journal ArticleDOI
Spectrofluorometric determination of the toxic constituents of Cleistanthus collinus.
TLDR
Spectrofluorometric quantitation of a lignan lactone, diphyllin, and its glycosides cleistanthin A and Cleistanthin B, the active principles of the poisonous plant Cleistanthus collinus, is reported for the first time.Abstract:
Spectrofluorometrlc quantltatlon of a Ilgnan lactone, diphyllin, and its glycosides cleistanthin A and cleistanthin B, the active principles of the poisonous plant Ctelstanthus collinus, is reported for the first time. Thin layer chromatographic resolution of the components precedes the fluorometric measurements. The method is highly reproducible and sensitive to 0.1 pg/mL for diphyllln and to 1 pg/mL for cleistanthins A and B in ethanol. The technique is employed for the assay of several biospeclmens of forensic and clinical importance.read more
Citations
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Journal ArticleDOI
Patterns and problems of deliberate self‐poisoning in the developing world
TL;DR: It is emphasized the importance of determining whether interventions aimed at reducing poison absorption actually produce a clinical benefit, reducing death and complication rates, to rapidly reduce the number of deaths from self-poisoning in the developing world.
Journal ArticleDOI
Cleistanthus collinus poisoning: case reports and review of the literature.
TL;DR: Two previously healthy young patients who ingested the liquid extracted from the crushed leaves of Cleistanthus collinus in an attempt to commit suicide developed life threatening complications and ultimately died.
Journal Article
A clinical and laboratory profile of Cleistanthus collinus poisoning.
TL;DR: It is a poisoning seen in the young with significant mortality, mainly due to its cardiac and respiratory effects, and laboratory abnormalities such as hypokalaemia, hyponatremia, an elevated AST/LDH/CPK/ CPK-MB, nonspecific ST-T changes and QTc prolongation on ECG, metabolic acidosis and hypoxia with widened alveolar-arterial oxygen difference (A-aDO2) were seen in both groups.
Book ChapterDOI
New findings on the bioactivity of lignans
TL;DR: This chapter reviews the lignans with biological and pharmacological activity, and includes new natural products and some synthetic or semisynthetic compounds.
Journal ArticleDOI
Cleistanthus collinus poisoning
TL;DR: Toxin effect in animal models demonstrate neuromuscular blockade with muscle weakness, distal renal tubular acidosis (dRTA) and type 2 respiratory failure with conflicting evidence of cardiac involvement, and studies suggest a likely inhibition of thiol/thiol enzymes by the lignan-lactones, depletion of glutathione and ATPases in tissues.
References
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Journal ArticleDOI
Chemical constituents of Cleistanthus collinus (Roxb.)
TL;DR: In this paper, Ellagic acid, diphyllin and two new lignan lactones, cleistanthin and collinusin, have been isolated from Cleistanthus collinus (Roxb).