Patent
Spiro-polycyclicimidazolidinedione derivatives
Sarges R,Belletire J +1 more
TLDR
Novel spiro-polycyclicimidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed as discussed by the authors.Abstract:
Novel spiro-polycyclicimidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include 2',3'-dihydro-spiro[imidazolidine-4,4'-[4'H]-naphtho[1,2-b]pyran]-2,5-dione, 2',3'-dihydro-spiro-[imidazolidine-4, 4'-[4'H]-naphtho[1,2-b]thiopyran]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-benz[a]anthracene]2,5-dione, 2',3'-dihydro-spiro[imidazolidine-4,1'phenalene]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-phenanthrene]-2,5-dione, the 2,1 isomers of the 2',3'-dihydro-4'H-pyran and 2',3'-dihydro-4'H-thiopyran derivatives, the 2',3'-dihydro-4'H-anthracenopyran and 2',3'-dihydro-4'H-anthracenothiopyran derivatives, the spiro-4,4' isomer of the tetrahydrophenanthrene derivative, the [b] isomer of the benzanthracene derivative and the mono or disubstituted 2',3'-dihydro-4'H-naphthopyran, 2',3'-dihydro-4'H-naphthothiopyran and tetrahydrophenanthrene derivatives.read more
Citations
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References
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Patent
Hydantoin derivatives as therapeutic agents
TL;DR: A series of spiro-hydantoin compounds have been prepared by condensing the appropriate carbonyl ring compound, such as the corresponding 1-indanone, 1-tetralone, 4-chromanone and 4-oxoisothiochroman-2,2-dioxide, with potassium cyanide and ammonium carbonate as discussed by the authors.
Patent
Compositions for and a method of treating diabetic complications
TL;DR: In this paper, the pharmaceutical compositions of this invention comprises 1,3dioxo-1H-benz( de)isoquinoline-2(3H)-acetic acid, and optionally substituted derivatives thereof together with their pharamaceutically acceptable salts.
Patent
Hydantoin therapeutic agents
TL;DR: Several dextrotatory spiro-hydantoin compounds have been obtained by resolving the corresponding dl-compounds which are initially synthesized by first condensing the appropriate carbonyl ring compound, such as the corresponding 4-chromanone or thiochroman-4-one, with potassium cyanide and ammonium carbonate.