Alcon

About: Alcon is a company organization based out in Beijing, China. It is known for research contribution in the topics: Ocular hypertension & Glaucoma. The organization has 998 authors who have published 1051 publications receiving 33119 citations. The organization is also known as: Alcon, Inc..

Polyimides: Fundamentals and Applications

Abstract: "Introduction History of the Invention and Development of the Polyimides, C. E. Sroog Synthesis Synthesis of Polyimides, Tohru Takekoshi Synthesis of Polyamideimides, Yoshio Imai Synthesis of Fluorinated Polyimides, Shigekuni Sasaki and Shiro Nishi Photosensitive Polyimides, Molecular Design and Synthesis, Toshihiko Omote Chemistry and Kinetics of Polyimide Formation, James M. Sonnett and Thomas P. Gannett Vapor Phase Deposition of Polyimides, Thomas Strunskus and Michael Grunze Bulk Properties and Modifications Thermal Curing in Polyimide Films and Coatings, John C. Coburn and Michael T. Pottinger Infrared Curing of Polyimides, John G. Stephanie and Paul G. Rickerl Sorption and Diffusion of Water Vapor in Polyimide Films, Ken-ichi Okamoto Charge Transfer in Aromatic Polyimides, Joseph M. Salley and Curtis W. Frank Dielectric Properties of Polyimides and Factors Influencing Such Properties, Ressano De Souza-Machado, Shien-Yang Wu, and Denice D. Denton Degradation and Stability of Polyimides, James A. Cella Surface Characterization, Modification, and Adhesion Aspects Surface Characterization of Polyimides, Fabio Garbassi, Marco Morra, and Ernesto Occhiello Plasma Surface Modification and Etching of Polyimides, Frank D. Egitto and Luis J. Matienzo Laser Ablation of Polyimides, George H. Pettit Ion Beam Modification of Polyimides, Eal H. Lee Wet Chemical Modification of Polyimide Surfaces: Chemistry and Application, Kang-Wook Lee and Alfred Viehbeck Tribological Behavior of Polyimides, U.S. Tewari and J. Bijwe Adhesion of Polyimides to Various Substrates, L. Paivikki Buchwalter Adhesion of Metal Films to Polyimides, Luis J. Matienzo and William N. Unertl Applications Polyimides for Gas Separation, Michael Langsam Applications of Polyimides as Photosensitive Materials, Jean-Marc Bureau and Jean-Paul Droguet Polyimides in High-Performance Electronics Packaging and Optoelectronic Applications, Claudius Feger and Hilmar Franke Polyimides as Langmuir-Blodgett Films, Mitsumasa Iwamoto and Masa-aki Kakimoto "

Breast Cancer Subtypes Based on ER/PR and Her2 Expression: Comparison of Clinicopathologic Features and Survival

Abstract: Over the last few decades there have been outstanding advances in breast cancer management leading to earlier detection of disease and the development of more effective treatments resulting in significant declines in breast cancer deaths and improved outcomes for women living with the disease.1,2 Breast cancer is no longer seen as a single disease but rather a multifaceted disease comprised of distinct biological subtypes with diverse natural history, presenting a varied spectrum of clinical, pathologic and molecular features with different prognostic and therapeutic implications. Consensus regarding the definitive prognostic/predictive analysis has yet to be reached, but significant progress continues to be made in the ongoing search for a specific, rigorous and reproducible method of identifying successful treatment algorithms utilizing biological markers. Recent attention has been directed singularly at molecular classifications of breast cancer.3–11 While molecular and genetic testing is very elegant, prognostic and predictive, it is expensive and not yet widely available. Also, despite the prognostic information provided by the molecular test, current reports of assay results impart little specific guidance of response to targeted and proven therapy; for example, endocrine and trastuzumab therapy for tumors expressing estrogen receptor/progesterone receptor (ER/PR) or human epidermal growth factor receptor 2 (Her2) proteins, respectively. The immunohistochemistry (IHC) classification provides both therapeutic and prognostic information. In this study breast cancer is classified into four groups based on IHC profile ER/PR and Her2/neu expression, positive (+) and/or negative (−). The groups are: ER/PR+, Her2+ = ER+/PR+, Her2+; ER−/PR+, Her2+; ER+/PR−, Her2+ ER/PR+, Her2− = ER+/PR+, Her2−; ER−/PR+, Her2−; ER+/PR−, Her2− ER/PR−, Her2+ = ER−/PR−, Her2+ ER/PR−, Her2− = ER−/PR−, Her2− The IHC classification correlates well with intrinsic gene expression microarray categorization: ER/PR+, Her2+ with Luminal B; ER/PR+, Her2− with Luminal A; ER/PR−, Her2+ and ER/PR−, Her2− with triple negative/basal-like tumors.1 Apart from lending itself to subtype analyses of tumor when fresh tissue is not available, the IHC classification has prognostic and therapeutic implications, is inexpensive and readily available.

Surgical cassette proximity sensing and latching apparatus

Abstract: There is disclosed herein a system for providing control of multiple functions needed to perform eye surgery. A microprocessor based system controls a vacuum generation system using venturis and linear valves and a pneumatic system for driving vitrectomy probes and pneumatic scissors in either a variable frequency, multicut mode or a proportional cut mode where the cutting pressure is proportional to the position of a foot operated position sensor. The frequency of the vitrectomy probe cutting action can also be controlled and the level of vacuum can be controlled from a foot operated position sensor which can also be used to turn on or off a fragmentation device. The footswitch can also be used to turn irrigation fluid on or off, and the flow rate can be controlled from a control on the front panel. By making a certain foot motion in any certain aspiration modes, reflux of the aspiration line can be controlled. The vacuum level is continuously monitored over all aspiration conditions and adjusted to stay as close as possible to the desired vacuum level. A cassette proximity sensing system senses the presence of a cassette, and aids the user in drawing in and latching the cassette. The vacuum integrity of the cassette is automatically checked by the microprocessor each time one is drawn into the machine. The microprocessor also monitors the cassette for fullness an initiates a transfer to empty one bottle of the cassette into another bottle for storage when the first bottle becomes full. A back-up system checks the accuracy of cassette liquid level sensing apparatus by double checking for liquid in the line leading to the vacuum generation system. If water is detected, a fluid transfer from one bottle of the cassette to the other is initiated.

Carbonic anhydrase inhibitors

Abstract: Compounds of the following formula are disclosed: Compounds of Formula I are the topic of this invention: ##STR1## Wherein G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from ##STR2## The compounds are useful as carbonic anhydrase inhibitors.