Patent
Straight-chain fluorine-containing anionic compound and its preparation
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TLDR
In this article, a fluorine-containing surface active agent is used as a foam fire extinguishant, foaming agent, etc having improved stability to change is pH process, where the fluorine is reacted with an alkali metal salt of sulfite in an organic solvent at 0-150 degC for 3-25hr, to give a compound shown by the formula I when A is SO3 and M is Na.Abstract:
NEW MATERIAL:A compound shown by the formula I [Rf is 1-20C polyfluoroalkyl, polyfluoroalkenyl, etc; Z is bifunctional connecting group; Q1 is (CH2)l (l is 1-6), (CH2)m-O-(CH2)n (m and n are 2-6), etc; R is H, 1-6C alkyl, etc; a is 0, or 1; Y is O, or S(O when a=0); Q2 is group shown by the formula II(s, t, u, and v are 0-6), etc; A is anion such as COO , SO3 , etc; M is H, or cation] USE:An anionic fluorine-containing surface active agent Useful as a foam fire extinguishant, foaming agent, etc having improved stability to change is pH PROCESS:A fluorine-containing compound shown by the formula III (X is Cl, Br, or I) is reacted with an alkali metal salt of sulfite (eg, potassium sulfite, sodium sulfite, etc) in an organic solvent at 0-150 degC for 3-25hr, to give a compound shown by the formula I (when A is SO3 and M is Na)read more
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Sulfonamide inhibitors of aspartyl protease
TL;DR: In this paper, a class of sulfonamide compounds of formula I which are aspartyl protease inhibitors are presented. But they are not suitable for use as anti-viral agents against the HIV-1 and HIV-2 viruses.
Patent
Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors
Tung Roger D,Michael R. Hale,Baker Christopher T,Furfine Eric Steven,Istvan Kaldor,Kazmierski Wieslaw Mieczyslaw,Andrew Spaltenstein +6 more
TL;DR: In this paper, a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient is presented.
Patent
Inhibitors of aspartyl protease
Michael R. Hale,Baker Christopher T,Timothy A Stammers,Ronald George Sherrill,Andrew Spaltenstein,Eric Steven Furfine,Francois Maltais,Andrews Clarence Webster,John F. Miller,Vicente Samano +9 more
TL;DR: In this article, the authors provide novel compounds of formula (I) where all variables are as defined in the specification, that are useful as inhibitors of aspartyl proteases.
Patent
Thf-containing sulfonamide inhibitors of aspartyl protease
TL;DR: In this paper, a class of THF-containing sulfonamides which are aspartyl protease inhibitors are described. But, they are not suitable for use as anti-viral agents against the HIV-1 and HIV-2 viruses.
Patent
Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease
TL;DR: In this article, a compound of formula I can be substituted with one or more substituents from a group consisting of -C(O)-, -S(O)2-N(R )(R), -S (O)n-R, -N (R )-S(R)2(R ), halo, -CF3, -NO2, -R and -O-R ; each R is independently selected from the group, including C1-C6-alkyl, and each E is Het.
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Controller for combustor
Harada Yutaka,Isao Shinoda +1 more
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