Journal ArticleDOI
Study of 1,26,266 consecutive births for major congenital defects.
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The frequency of congenital defects was noted to decline with increasing maternal age, 21–25 years age group had maximum number of malformed babies, whereas cleft palate with/without hare lip had highest frequency during winter.Abstract:
Retrospective study was carried out in 1,15,851 consecutive births in five hospitals, and prospective study of 10,415 consecutive births in one hospital of West Bengal. The overall frequency of congenital defects was 4.42/1000 live births. Incidence of NTD and talipes was predominant in rainy season, whereas cleft palate with/without hare lip had highest frequency during winter. Incidence of these anomalies decreased with increasing birth order. The frequency was noted to decline with increasing maternal age, 21-25 years age group had maximum number of malformed babies. Sex ratio and religion, however, did not have any correlation with the incidence of these malformations. When comparison was done between urban and rural population no statistically significant variation was observed.read more
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Parent's age and the risk of oral clefts.
Camilla Bille,Axel Skytthe,Werner Vach,Lisbeth B. Knudsen,Anne-Marie Nybo Andersen,Jeffrey C. Murray,Kaare Christensen +6 more
TL;DR: Both high maternal age and high paternal age were associated with cleft lip with or without cleft palate, but the contribution of each was dependent on the age of the other parent.
Journal ArticleDOI
Parental age as a risk factor for non-syndromic oral clefts: a meta-analysis.
Ana Paula Corrêa de Queiroz Herkrath,Fernando José Herkrath,Maria Augusta Bessa Rebelo,Mario Vianna Vettore +3 more
TL;DR: It is suggested that fathers forty years of age or older had a 58% higher probability of having a child with cleft palate compared to those aged between 20 and 39 years, and no evidence of association between early maternal and paternal age with occurrence of oral clefts was observed.
Journal ArticleDOI
Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: a systematic review and meta-analysis.
TL;DR: A systematic review aimed to understand the birth prevalence of clubfoot in LMIC settings.
Journal ArticleDOI
Birth Prevalence of Neural Tube Defects and Orofacial Clefts in India: A Systematic Review and Meta-Analysis
Komal Preet Allagh,BR Shamanna,Gudlavalleti V S Murthy,Andy R Ness,Pat Doyle,Sutapa B Neogi,Hira B Pant +6 more
TL;DR: The overall prevalence of neural tube defects from India is high compared to other regions of the world, while that of orofacial clefts is similar to other countries.
Journal ArticleDOI
Congenital malformations at birth--a prospective study from south India.
B. Vishnu Bhat,Lokesh Babu +1 more
TL;DR: Congenital malformations were studied prospectively from September 1989 to December 1992 covering 12,797 consecutive deliveries and musculoskeletal, cutaneous and genitourinary mal Formations were common among live born babies while central nervous system and gastrointestinal defects wereCommon among still born babies.
References
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Congenital malformations : a report of a study of series of consecutive births in 24 centres
TL;DR: A report is presented of a study of births in 24 centers in 16 countries with respect to the occurrence and type of ciongenital malformations found in still born and liveborn infants, where there is a marked association between consanquinity of parents with increases stillbirth rates and frequency of early death of an infant.
Journal ArticleDOI
International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper 5/6. Perspectives in mutation epidemiology, 6. A 1983 view of sentinel phenotypes.
TL;DR: A sentinel phenotype is a clinical disorder or syndrome that occurs sporadically as a consequence of a single, highly penetrant mutant gene, and is a dominant or X-linked trait of considerable frequency and low fitness as discussed by the authors.
Journal ArticleDOI
Mutation surveillance of sentinel anomalies in Hungary, 1980–1984
TL;DR: The Hungarian Congenital Malformation Registry, 1980-1984 was used to detect sentinel malformation in Hungarian children as discussed by the authors, and the revised total observed prevalence of 25 sentinel anomalies was 3.80 per 10000 live births.
Journal ArticleDOI
East-West differentials in congenital malformations in India.
P. K. Chinara,Shamer Singh +1 more
TL;DR: A survey of the congenitally anomalous babies revealed the incidence to be 2.08% at birth in 1774 births from 1736 mothers who delivered in Banaras Hindu University Hospital during a period of 12 months (1978–79).
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