Journal ArticleDOI
Surgical Staging of Abdominal Involvement in Unselected Patients with Hodgkin's Disease
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TLDR
Larotomy with splenectomy and liver and para-aortic lymph node biopsies appears valuable for precise staging of intra-abdominal Hodgkin's disease.Abstract:
Fifty unselected patients with untreated Hodgkin's disease underwent diagnostic laparotomy, splenectomy, liver biopsy, and para-aortic lymph node biopsy as part of their evaluations. Histologic findings in para-aortic nodes, liver, and spleen are presented. No instance of liver involvement without concomitant splenic involvement was noted. Approximately 30% of patients whose preoperative work-up was negative or inconclusive proved to have unsuspected Hodgkin's disease, primarily in spleen and lymph nodes of splenic hilus. Left supraclavicular adenopathy appeared to correlate with intra-abdominal disease. Laparotomy with splenectomy and liver and para-aortic lymph node biopsies appears valuable for precise staging of intra-abdominal Hodgkin's disease.read more
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Clinicopathologic studies of 117 untreated patients subjected to laparotomy for the staging of Hodgkin's disease
TL;DR: The pathologic findings in 117 untreated patients subjected to laparotomy for the staging of Hodgkin's disease were correlated with the preoperative clinical evaluation and the validity and applicability of the modified classification of Lukes, Butler, and Hicks were confirmed.
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Hodgkin's disease: unfolding concepts concerning its nature, management and prognosis.
TL;DR: Total lymphoid megavoltage radiotherapy and/or multidrug combination chemotherapy now permit the eradication of disease of all stages, resulting in a dramatic improvement in prognosis and an increasing frequency of permanent cure of this once inevitably fatal condition.
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Histopathology of malignant lymphomas
TL;DR: In this article, the classification of non-Hodgkin's lymphomas has been discussed and the historical development of concepts relating to terminology and classification of Hodgkin's disease and the non- Hodgkin lymphomas have been explored and discussed.
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A decade of combination chemotherapy of advanced Hodgkin's disease.
TL;DR: The results of this combined drug program and of several other studies employing combinations of effective drugs consistently show a higher rate of induction of complete remissions in patients with advanced Hodgkin's disease and prolongation of remission duration after all therapy is stopped.
References
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Natural history of Hodgkin's disease as related to its pathologic picture
TL;DR: The authors suggest that the Hodgkin's disease process represents the attempted induction of malignant neoplasia and that the evolution of the histologic process is a manifestation of the natural history of the disease.
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The value of laparotomy and splenectomy in the staging of Hodgkin's disease.
TL;DR: It is concluded that laparotomy with splenectomy is a valuable procedure for the more precise delineation of intra‐abdominal sites of involvement in Hodgkin's disease prior to the initiation of extended field megavoltage radiation therapy with curative intent.
Journal Article
Evidence for an orderly progression in the spread of Hodgkin's disease.
TL;DR: These observations support the concept that Hodgkin9s disease arises in a single focus and spreads in a predictable manner along adjacent lymphoid channels, as well as the therapeutic implications of these observations.
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