Susceptibility of Helicobacter pylori to mupirocin, oxazolidinones, quinupristin/dalfopristin and new quinolones
José Elías García Sánchez,Natalia García Sáenz,Manuel Rodríguez Rincón,Ignacio Martín,Enrique García Sánchez,María José Fresnadillo Martínez +5 more
TLDR
The in vitro activities of mupirocin, quinupristin/dalfopristin, linezolid, eperezolid, sitafloxacin, clinafloxacIn, moxifloxacsin, amoxycillin, metronidazole and clarithromycin were tested against 57 strains of Helicobacter pylori to find the most active and least active agents.Abstract:
The in vitro activities of mupirocin, quinupristin/dalfopristin, linezolid, eperezolid, sitafloxacin, clinafloxacin, moxifloxacin, amoxycillin, metronidazole and clarithromycin were tested at pH 7.4 against 57 strains of Helicobacter pylori. The most active agents (mupirocin, sitafloxacin and clinafloxacin) were also tested for activity at pH 5.4 against the same strains. Mupirocin was very active at pH 7.4 and 5.4 (MIC90 0.25 and 0.12 mg/L, respectively). Quinupristin/dalfopristin, linezolid and eperezolid had low activity (MIC90 4, 8 and 4 mg/L, respectively). Sitafloxacin (MIC90 </= 0.008 mg/L) was the most active fluoroquinolone, while clinafloxacin (MIC90 0.12 mg/L) and moxifloxacin (MIC90 2 mg/L) were least active.read more
Citations
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Systematic review and meta-analysis: levofloxacin-based rescue regimens after Helicobacter pylori treatment failure.
TL;DR: A quadruple therapy has been generally recommended as rescue regimen for Helicobacter pylori eradication failures.
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Levofloxacin-Based Triple Therapy versus Bismuth-Based Quadruple Therapy for Persistent Helicobacter pylori Infection: A Meta-Analysis
TL;DR: A 10-day course levofloxacin-based triple therapy is more effective and better tolerated than 7-day bismuth-based quadruple therapy in the treatment of persistent H. pylori infection.
Journal ArticleDOI
Single and Double Mutations in gyrA but Not in gyrB Are Associated with Low- and High-Level Fluoroquinolone Resistance in Helicobacter pylori
TL;DR: The six resistant clinical strains and three ciprofloxacin-selected single-step mutants studied carried one gyrA mutation but none in gyrB, and fluoroquinolones were the most active fluoroquolones against these mutants.
Journal ArticleDOI
A 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses.
Luigi Gatta,A. Zullo,F. Perna,Claudio Ricci,V. De Francesco,A. Tampieri,Veronica Bernabucci,M. Cavina,Cesare Hassan,Enzo Ierardi,S. Morini,Dino Vaira +11 more
TL;DR: A standard third‐line treatment is lacking, and European guidelines recommend performing culture in patients, but the use of this procedure as ‘routine practice’ is definitively not feasible.
Journal ArticleDOI
Primary levofloxacin resistance and gyrA/B mutations among Helicobacter pylori in Japan.
Hideyuki Miyachi,Ikuya Miki,Nobuo Aoyama,Daisuke Shirasaka,Yuko Matsumoto,Masanori Toyoda,Toshifumi Mitani,Yoshinori Morita,Takao Tamura,Shohiro Kinoshita,Yoshie Okano,Shunichi Kumagai,Masato Kasuga +12 more
TL;DR: The use of levofloxacin‐containing therapy as a treatment for Helicobacter pylori eradication has been considered a promising regimen, but there is a little information concerning the prevalence of lev ofl Oxacin resistance and this resistance mechanism.
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