Synthesis of caffeine from theobromine: Bringing back an old experiment in a new setting
Davir González-Calderón,Carlos A. González-González,Aydeé Fuentes-Benítes,Carlos González-Romero +3 more
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In this article, the synthesis of theobromine is described as an experiment for the undergraduate organic chemistry laboratory and the N-methylation is monitored by TLC using authentic standards.About:
This article is published in Educación Química.The article was published on 2015-01-01 and is currently open access. It has received 11 citations till now. The article focuses on the topics: Theobromine.read more
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Selected C8 two-chain linkers enhance the adenosine A1/A2A receptor affinity and selectivity of caffeine.
TL;DR: In this article, various C8 two-chain-length linkers to enhance adenosine receptor affinity were evaluated and the results indicated that the unsubstituted benzyloxy linker (1e A1Ki = 1.52μm) displayed the highest affinity for the A1 adenosinesine receptor and the para-chloro-substitized phenoxymethyl (1d A2AKi= 1.33μM) linker the best affinity for A2A receptor affinity.
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Safety issues of compounds acting on adenosinergic signalling.
Jan Schmidt,Polonca Ferk +1 more
TL;DR: The aim was to examine the toxicological and adverse effects data of different compounds acting on adenosinergic signalling, including different AdR ligands and compounds resembling the structure of adenosine.
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Optimized Isolation Procedure for the Extraction of Bioactive Compounds from Spent Coffee Grounds
Theodoros Chatzimitakos,Vassilis Athanasiadis,Konstantina Kotsou,Dimitrios Palaiogiannis,Eleni Bozinou,Stavros Lalas +5 more
TL;DR: In this paper , the main parameters affecting the extraction of caffeine and polyphenols (i.e., chlorogenic acid, neochlorogenic acid and caffeic acid) were investigated, and the antioxidant properties of the extracts were evaluated.
Journal Article
Attractiveness of bioinsecticides caffeine and used coffee grounds in the choice of oviposition site by Aedes aegypti (Diptera: Culicidae)
TL;DR: Two experiments were carried out aiming to verify if CAF aqueous solution and UCG suspension might interfere in the choice of the oviposition site by Aedes aegypti, and reinforce the possibility of using CAF andUCG as auxiliaries in the control of Ae.
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Chromatographic Separation of Phosphoric Acid from Cola Beverages
TL;DR: In this article, the authors carried out the chromatographic separation of phosphoric acid by using an anionic exchange resin (Dowex 1-XH 100-200 mesh, Bio-Rad).
References
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Emil Fischer—Unequalled Classicist, Master of Organic Chemistry Research, and Inspired Trailblazer of Biological Chemistry
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Determination of Caffeine, Theobromine, and Theophylline in Standard Reference Material 2384, Baking Chocolate, Using Reversed-Phase Liquid Chromatography
Jeanice M. Brown Thomas,James H. Yen,Michele M. Schantz,Barbara J. Porter,Katherine E. Sharpless +4 more
TL;DR: A rapid and selective isocratic reversed-phase liquid chromatographic method has been developed at the National Institute of Standards and Technology to simultaneously measure caffeine, theobromine, and theophylline in a food-matrix standard reference material (SRM) 2384, Baking Chocolate.
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N-alkylation of amides and n-heterocycles with potassium fluoride on alumina
TL;DR: Alumina coated with potassium fluoride promotes smooth N-alkylation of carboxamides, lactams, and other N-heterocycles with alkyl halides or dialkyl sulfate under mild conditions as mentioned in this paper.
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Determination of caffeine content in coffee using Fourier transform infra-red spectroscopy in combination with attenuated total reflectance technique: a bioanalytical chemistry experiment for biochemists
TL;DR: An experiment to estimate the amount of caffeine present in common beverages with the use of Fourier transform infra-red spectroscopy (FTIR), using an attenuated total reflectance accessory as a sampling system.
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Quantitative determination of caffeine in beverages using a combined SPME-GC/MS method
TL;DR: The analytical conditions and data for determination of caffeine in coffee, tea, and coke are presented and the simplicity of the SPME-GC/MS method lends itself to a good undergraduate laboratory practice.