Journal ArticleDOI
The challenges of genome sequence annotation or "the devil is in the details".
Temple F. Smith,Xiaolin Zhang +1 more
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This article is published in Nature Biotechnology.The article was published on 1997-11-01. It has received 567 citations till now. The article focuses on the topics: Vertebrate and Genome Annotation Project & Genome project.read more
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An efficient algorithm for large-scale detection of protein families
TL;DR: This work presents a novel approach called TRIBE-MCL for rapid and accurate clustering of protein sequences into families based on precomputed sequence similarity information that has been rigorously tested and validated on a number of very large databases.
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Prediction of protein function from protein sequence and structure.
TL;DR: The state of the art in function prediction is reviewed and some of the underlying difficulties and successes are described, including inferring conservation patterns in members of a functionally uncharacterized family for which many sequences and structures are known.
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Errors in genome annotation.
TL;DR: This analysis compares three different groups' functional annotation for the Mycoplasma genitalium genome, and finds that the results are disappointing for those expecting reliable annotation.
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Practical Limits of Function Prediction
Damien P. Devos,Alfonso Valencia +1 more
TL;DR: A critical view of the theoretical and practical bases for the practice of assigning a potential function to a protein on the basis of sequence similarity to proteins whose function has been experimentally investigated is presented.
References
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The ancient regulatory-protein family of WD-repeat proteins
TL;DR: WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD), and criteria for grouping such proteins into functional subfamilies are defined.