Journal ArticleDOI
The characterization of substituted nitroimidazoles on paper and thin layer chromatography by colorimetric reactions
J.E. Stambaugh,R.W. Manthei +1 more
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TLDR
2-Methyl-4(5)-nitroimidazoles reacted with Ninhydrin to yield a characteristic green color, a new color reaction for this reagent and appears to involve condensation of the ninhydrin molecule on an active methylene group on an imidazole ring.About:
This article is published in Journal of Chromatography A.The article was published on 1967-01-01. It has received 16 citations till now. The article focuses on the topics: Ninhydrin & Color reaction.read more
Citations
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Journal ArticleDOI
Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles
Donald G. Lindmark,Miklós Müller +1 more
TL;DR: The results underscore the role of the reduction of the nitro group in the antitrichomonad and in the mutagenic activity of nitroimidazoles.
Journal Article
Hypoxia-dependent Reduction of 1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese Hamster Ovary Cells and KHT Tumor Cells in Vitro and in Vivo
TL;DR: Investigation of incubation of Chinese hamster ovary cells and KHT murine fibrosarcoma tumor cells with 1-[2-14C]nitro-1-imidazolyl)-3-methoxy-2-propanol suggests that some nitro compounds may be useful for the treatment of tumors having a high fraction of hypoxic cells even in the absence of radiation.
Book ChapterDOI
Advances in Imidazole Chemistry
TL;DR: In this article, a review of the developments in imidazole chemistry is presented, including the properties of the 1-acylimidazoles (imidazolides), which are extremely reactive in such nucleophilic reactions as hydrolysis and alcoholysis.
Journal ArticleDOI
Effect of metronidazole on hydrogen production by Clostridium acetobutylicum
TL;DR: It seems that additional reasons might have to be sought to explain the unique effectiveness of metronidazole as an antimicrobial agent.
Journal ArticleDOI
Absorptiometric, Polarographic, and Gas Chromatographic Assays for the Determination of N-1-substituted Nitroimidazoles in Blood and Urine
TL;DR: The absorptiometric assay was used in the determination of blood level fall-off curves and urinary excretion of each compound in a dog following the administration of single 10-mg./kg dose, while the GLC assay was use to extend the limits of detection of the absorpt iometric assay and to determine the blood level falls-off curve in man following a single oral 50-mg.
References
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Journal ArticleDOI
A new coupling component for sulfanilamide determination
A. Calvin Bratton,E. K. Marshall +1 more
Journal ArticleDOI
Studies on imidazole compounds; a synthesis of imidazoles with functional groups in the 2-position.
Journal ArticleDOI
The metabolism of metronidazole (1 -2′-hydroxyethyl-2-methyl-5-nitroimidazole)
TL;DR: The urine contained unchanged metronidazole, the corresponding acid, 2-methyl-5-nitroimidazoles-1-ylacetic acid, and a second metabolite which has been tentatively identified as the ether glucuronide of metronidsazole (III).
Related Papers (5)
Erratum: Mechanism of the ninhydrin reaction. II. Preparation and spectral properties of reaction products from primary aromatic amines and ninhydrin hydrate
Modified ninhydrin reagents to detect amino acids on TLC plates
A color reaction and thin layer chromatography of aromatic nitroso compounds
Kenji Yasuda,Kyozo Nakashima +1 more