Journal ArticleDOI
The effect of alterations in thyroid function on the pituitary growth hormone content and acidophil cytology.
Jolane Solomon,Roy O. Greep +1 more
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TLDR
The pituitaries of female rats subjected to various alterations in thyroid function were examined for changes in hypophyseal growth hormone content and acidophil morphology, and neither the pituitary cytology nor the hormonal level was restored to normal.Abstract:
The pituitaries of female rats subjected to various alterations in thyroid function were examined for changes in hypophyseal growth hormone content and acidophil morphology. Thyroidectomy caused a significant decrease in the amount of growth hormone as well as a decrease in the acidophil granulation and population, whereas subsequent treatment with thyroxine allowed the pituitary structure and growth hormone content to return to normal. The pituitaries of unoperated rats fed a diet containing thyroid powder contained less growth hormone than those from normal controls, and the population and granulation of the pituitary acidophils were decreased. The pituitary growth hormone content of thyroidectomized rats fed a diet containing 2,4-dinitrophenol was increased above thyroidectomy levels, but neither the pituitary cytology nor the hormonal level was restored to normal. The same diet fed to unoperated rats did not significantly alter the pituitary growth hormone levels and structure.read more
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Sexual dimorphism in the control of growth hormone secretion.
TL;DR: A feminization of the liver develops after continuous, but not intermittent, administration of GH to hypophysectomized rats, suggesting that high, infrequent GH pulses with low plasma GH levels in between promotes growth more effectively than an intermediate, rather constant level of plasma GH.
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Thyroid Hormone Action: A Cell-Culture System Responsive to Physiological Concentrations of Thyroid Hormones
TL;DR: Dose-response relationships of a vacriety of thyronine derivatives indicate that this rat pituitary tumor cell line has a specificity of response which is similar to that observed in vitro.
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Skeletal Muscle Cell Mass and Growth: The Concept of the Deoxyribonucleic Acid Unit
TL;DR: Two important predictions, contradicting current opinion, arise from his review:Removal of the pituitary causes loss of muscle deoxyribonucleic acid (DNA) in the weanling rat and calorie restriction imposed during the postweanling period of growth in rats does slow cell multiplication but does not cause permanent growth retardation.
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Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process
TL;DR: Studies on the effect of actinomycin D, 3'-deoxyadenosine, and cycloheximide support the thesis that L-triiodothyronine induces the accumulation of an RNA species which is rate limiting for growth hormone synthesis and lends further support for a primary action of thyroid hormone at the nuclear level.
Journal ArticleDOI
Relationship of receptor affinity to the modulation of thyroid hormone nuclear receptor levels and growth hormone synthesis by L-triiodothyronine and iodothyronine analogues in cultured GH1 cells.
TL;DR: The observation that thyroid hormone influences dispersed rat pituitary cells in a fashion qualitatively similar to GH1 cells may have implications for the growth hormone response of the somatotroph cell in vivo to different thyroidal states.