Journal ArticleDOI
The metabolic significance of proteinbound iodine of plasma: a study of its concentration under various conditions and of its rate of formation as measured with radioactive iodine
TLDR
Its concentration in plasma was studied in rats shown to be completely deprived of thyroid tissue and in rats and guinea pigs in which hyperthyroidism had been induced.Abstract:
THE FRACTION of plasma iodine designated “protein-bound” is the iodine that is precipitated from plasma along with its proteins by such agents as tungstic acid, zinc hydroxide, or acetic acid in the presence of heat and in addition cannot be freed from these proteins by simple washing. Although the chemical identity of this fraction is as yet poorly understood, its concentration in plasma has gained wide use as an indicator of thyroid activity in man. (Salter et al., 1941; Man et al., 1942; Lowenstein et al., 1944; Talbot et al., 1944; Chaney, unpublished observations). In the present investigation, an attempt has been made to determine the metabolic significance of plasma protein-bound iodine. Its concentration in plasma was studied in rats shown to be completely deprived of thyroid tissue and in rats and guinea pigs in which hyperthyroidism had been induced. The use of radioactive iodine (I131) as a labeling agent also made possible a study of the rate of formation of protein-bound iodine in both states...read more
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Journal ArticleDOI
Chloric Acid Method for Determination of Protein-Bound Iodine
Journal ArticleDOI
The nature of the circulating thyroid hormone.
Alvin Taurog,I.L. Chaikoff +1 more
TL;DR: Two powerful tools, namely a refined method for determining small quantities of iodine and the radioactive isotope of iodine made possible a new attack on the problem of the nature of plasma iodine.
Journal ArticleDOI
Effect of Dietary Nitrate on Thyroid Function
TL;DR: Experimental results indicate that 0.31 and 0.92 percent dietary nitrate, when consumed by rats and sheep respectively, can affect the normal iodine metabolism of the thyroid gland.
Journal ArticleDOI
An appraisal of the radioiodine tracer technic as a clinical procedure in the diagnosis of the thyroid disorders; uptake measurement directly over the gland and a note on the use of thyrotropin (T.S.H.).
TL;DR: The tracer method used throughout has been that of direct measurement over the thyroid to determine the percentage uptake by the gland at twenty-four hours after an ingested dose of 40 microcuries of radioiodine, I131, carrier free.
Journal ArticleDOI
Physiological reactions of the thyroid-stimulating hormone.
TL;DR: It might be suggested that the increased collection of iodine by thyroids of animals previously treated with thyrotrophic hormone is independent of any direct action of the pituitary, but is related to an iodine want produced by a purging of the thyroid with TSH.
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