The pulmonary toxicity of antineoplastic agents.
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TLDR
The pathologic lesion associated with bleomycin has been most extensively studied, and because similar changes have been described for most agents, it will be described first.About:
This article is published in Seminars in Oncology.The article was published on 1982-03-01 and is currently open access. It has received 246 citations till now. The article focuses on the topics: Pulmonary toxicity & Pulmonary fibrosis.read more
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Pulmonary Drug Toxicity: Radiologic and Pathologic Manifestations
TL;DR: Pulmonary drug toxicity is increasingly being diagnosed as a cause of acute and chronic lung disease and knowledge of these manifestations and of the drugs most frequently involved can facilitate diagnosis and institution of appropriate treatment.
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Pulmonary Complications of Bone Marrow Transplantation
TL;DR: Antimicrobial prophylaxis, modified chemotherapy and irradiation dosages, and antiviral immunization have been shown to reduce the incidence of early-onset pulmonary problems.
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Mechanisms of bleomycin-induced lung damage
TL;DR: Bleomycins are a family of compounds produced by Streptomyces verticillis which have potent tumour killing properties which have given them an important place in cancer chemotherapy.
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Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice.
TL;DR: The results showed that a single instillation of bleomycin leads to the rapid appearance of apoptosis in bronchial and alveolar epithelial cells, which resolves within 1 day, and apoptosis reappears on day 7 and continues for over 14 days after bleomyin instillation.
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Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study.
Ann C. Mertens,Yutaka Yasui,Yan Liu,Marilyn Stovall,Ray Hutchinson,Jill P. Ginsberg,Charles A. Sklar,Leslie L. Robison +7 more
TL;DR: The Childhood Cancer Survivor Study is a resource that was designed to investigate long‐term effects among 5‐year survivors of childhood and adolescent malignancies.
References
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Journal ArticleDOI
A clinical review of bleomycin—a new antineoplastic agent
TL;DR: In conclusion, bleomycin appeared to be useful in the treatment of patients with specific tumors refractory to standard treatment and/or whose bone marrow status precluded the use of conventional chemotherapy.
Journal Article
The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.
TL;DR: The consistent induction of changes similar to those of diffuse pulmonary fibrosis or fibrosing alveolitis in man suggests that bleomycin-induced injury may provide a suitable model for the investigation of this ill-defined group of diseases.
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Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma.
Philip S. Schein,Vincent T. DeVita,Susan P. Hubbard,Bruce A. Chabner,George P. Canellos,Costan W. Berard,Robert C. Young +6 more
TL;DR: It is anticipated that the majority of patients with advanced, previously untreated, diffuse histiocytic lymphoma will achieve an extended disease-free survival for what had previously been regarded as an invariably fatal disease.
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Bleomycin, an Antitumor Antibiotic: Clinical Experience in 274 Patients
Alan Yagoda,Bijay Mukherji,Charles W. Young,Erlinda Etcubanas,Charles Lamonte,Julius R. Smith,Charlotte Tan,Irwin H. Krakoff +7 more