Open AccessJournal Article
The significance of quantitative temperature sense thresholds in diagnosis of small fibrous sensory neuropathy in patients with type 2 diabetes
TLDR
Quantitative analysis of temperature sense threshold can not only reflect increase of the pain threshold value, also can reflect its decrease, i.Abstract:
OBJECTIVE: To evaluate the small fiber function in patients with type 2 diabetes mellitus of the early stage by measuring the sensory threshold with the quantitative temperature testing technology. METHODS: Twenty cases of patients with type 2 diabetes with no neurological deficit (DM group) and twenty age and sex-matched healthy controls underwent the detecting of cold sensory threshold (CST), warm sensory threshold (WST), cold pain threshold (CPT), heat pain threshold (HPT) in both inside of their hands. RESULTS: There was no significant difference in CST, WST, CPT and HPT between left and right inside of hand of the same sample among all the testers. But the four kinds of threshold showed significant difference in the right inside of hand between patients and healthy people ( P < 0.05). In addition, the CST and WST differed significantly in the left inside of hand between the patients and healthy controls while the CPT and HPT showed no significant difference in the left inside of hand between them. Patients group and control group with CST and WST on the left side of the comparison difference was statistically significant (P < 0.05). CONCLUSION: Quantitative analysis of temperature sense threshold can not only reflect increase of the pain threshold value, also can reflect its decrease, i. e. hyperalgesia, which may help to diagnose small fibrous peripheral neuropathy recognition, especially in early diabetic peripheral neuropathy.read more
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Altered pain processing in patients with type 1 and 2 diabetes: systematic review and meta-analysis of pain detection thresholds and pain modulation mechanisms
TL;DR: This review synthesized the evidence for small-diameter nerve fiber neuropathy measured via quantitative sensory testing in patients with diabetes with and without painful and non-painful neuropathies and found that early detection is possible, which may assist in prevention and effective management of diabetic neuropathy.
Journal ArticleDOI
Research progress of the diagnosis of small fiber neuropathy
Kai-li Xian,Bao-xin Du +1 more
TL;DR: Progress of the examinational and diagnostic methods for the neuropathological, neuroelectrophysiological and autonomic nerve functions of SFN in recent years were introduced and nerve conduction velocity detection can detect the pathological changes of large fibers but not of small fibers, which lack of value in the diagnosis ofSFN.